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Entries
Maturation of spike protein
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authored
[InstanceEdit:9696918] Stephan, Ralf, 2020年07月22日
created
[InstanceEdit:9694660] Cook, Justin, 2020年07月07日
crossReference
[DatabaseIdentifier:11944893] Mondo:0100096
dbId
9694548
disease
[Disease:9683912] COVID-19
displayName
Maturation of spike protein
edited
[InstanceEdit:9698836] Stephan, Ralf, 2020年08月28日
eventOf
[Pathway:R-HSA-9694635] Translation of Structural Proteins - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:6677] viral protein processing
hasDiagram
false
hasEHLD
false
hasEvent
[BlackBoxEvent:R-HSA-9694793] Spike protein gets N-glycosylated - Homo sapiens
[BlackBoxEvent:R-HSA-9694364] N-glycan glucose trimming of Spike - Homo sapiens
[Reaction:R-HSA-9686790] ER-alpha glucosidases bind ER-alpha glucosidase inhibitors - Homo sapiens
[BlackBoxEvent:R-HSA-9696807] N-glycan mannose trimming of Spike - Homo sapiens
[Reaction:R-HSA-9694337] Trimmed spike protein binds to calnexin - Homo sapiens
[BlackBoxEvent:R-HSA-9694780] Spike translocates to ERGIC - Homo sapiens
[Reaction:R-HSA-9694341] Spike protein gets palmitoylated - Homo sapiens
[Reaction:R-HSA-9694467] Spike protein forms a homotrimer - Homo sapiens
[BlackBoxEvent:R-HSA-9694656] Spike trimer glycoside chains are extended - Homo sapiens
[BlackBoxEvent:R-HSA-9696980] Spike trimer glycoside chains get additional branches - Homo sapiens
[BlackBoxEvent:R-HSA-9697018] Addition of sialic acids on some Spike glycosyl sidechains - Homo sapiens
[BlackBoxEvent:R-HSA-9698333] Spike trimer moves into the ERGIC membrane - Homo sapiens
inferredFrom
[Pathway:R-HSA-9683686] Maturation of spike protein - Homo sapiens
isInDisease
true
isInferred
true
lastUpdatedDate
2022年09月14日
literatureReference
[LiteratureReference:9683050] Differential maturation and subcellular localization of severe acute respiratory syndrome coronavirus surface proteins S, M and E
[LiteratureReference:9763716] The Importance of Glycosylation in COVID-19 Infection
[LiteratureReference:9763712] The glycosylation in SARS-CoV-2 and its receptor ACE2
[LiteratureReference:9763718] Glycosylation of SARS-CoV-2: structural and functional insights
[URL:9763719] https://doi.org/10.1101/2021.05.14.444190
[URL:9763717] https://doi.org/10.31083/j.fbl2701003
maxDepth
2
modified
[InstanceEdit:9847082] Weiser, Joel, 2023年10月12日
name
Maturation of spike protein
precedingEvent
[BlackBoxEvent:R-HSA-9694447] mRNA2 is translated to Spike - Homo sapiens
relatedSpecies
[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate
2020年09月15日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9699044] Acencio, Marcio Luis, 2020年09月09日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-9694548
summation
[Summation:9694730] This COVID-19 pathway has been created by a combination of c...
updateTrackers
[UpdateTracker:9774743] Update Tracker - [Pathway:9694548] Maturation of spike protein - v81:[addHasEvent, updateContainedRLE]
[UpdateTracker:9774991] Update Tracker - [Pathway:9694548] Maturation of spike protein - v80:[add_removeLiteratureReference, modifyText, updateContainedRLE]
[UpdateTracker:9846999] Update Tracker - [Pathway:9694548] Maturation of spike protein - v82:[updateContainedRLE]
[UpdateTracker:9776417] Update Tracker - [Pathway:9694548] Maturation of spike protein - v76:[updateContainedRLE]
[UpdateTracker:9775518] Update Tracker - [Pathway:9694548] Maturation of spike protein - v78:[updateContainedRLE]
Referrals
(updatedInstance)
[UpdateTracker:9774743] Update Tracker - [Pathway:9694548] Maturation of spike protein - v81:[addHasEvent, updateContainedRLE]
[UpdateTracker:9774991] Update Tracker - [Pathway:9694548] Maturation of spike protein - v80:[add_removeLiteratureReference, modifyText, updateContainedRLE]
[UpdateTracker:9846999] Update Tracker - [Pathway:9694548] Maturation of spike protein - v82:[updateContainedRLE]
[UpdateTracker:9776417] Update Tracker - [Pathway:9694548] Maturation of spike protein - v76:[updateContainedRLE]
[UpdateTracker:9775518] Update Tracker - [Pathway:9694548] Maturation of spike protein - v78:[updateContainedRLE]
(hasEvent)
[Pathway:R-HSA-9694635] Translation of Structural Proteins
(inferredTo)
[Pathway:R-HSA-9683686] Maturation of spike protein
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