Reactome Pathway Database

Schema > Reaction > Entries

nsp15 binds RB1 Show undefined attributes

authored

[InstanceEdit:9697308] Orlic-Milacic, Marija, 2020年08月12日

category binding

compartment

[Compartment:70101] cytosol

created [InstanceEdit:9694660] Cook, Justin, 2020年07月07日

crossReference

[DatabaseIdentifier:11944893] Mondo:0100096

dbId 9694390

disease

[Disease:9683912] COVID-19

displayName nsp15 binds RB1

edited

[InstanceEdit:9697657] Orlic-Milacic, Marija, 2020年08月18日

eventOf

[Pathway:R-HSA-9694686] Replication of the SARS-CoV-2 genome - Homo sapiens

inferredFrom

[Reaction:R-HSA-9682712] nsp15 binds RB1 - Homo sapiens

input

isChimeric false

isInDisease true

isInferred true

literatureReference

[LiteratureReference:9682714] The coronavirus endoribonuclease Nsp15 interacts with retinoblastoma tumor suppressor protein

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

nsp15 binds RB1

output

[Complex:R-HSA-9694258] nsp15:RB1 [cytosol]

precedingEvent

[Reaction:R-HSA-9694436] nsp15 forms a hexamer - Homo sapiens

relatedSpecies

[Species:9681683] Severe acute respiratory syndrome coronavirus 2

releaseDate 2020年09月15日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:9699044] Acencio, Marcio Luis, 2020年09月09日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-9694390

summation

[Summation:9694628] This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.

Human SARS coronavirus 1 (SARS-CoV-1) non-structural protein 15 (nsp15) contains the LXCXE/D motif characteristic of proteins that bind to the retinoblastoma protein RB1. Binding to human RB1 increases the endonuclease activity of nsp15 but is not required for it. RB1 bound to nsp15 is retained in the cytosol. Interaction of nsp15 with RB1 likely affects the cell cycle of infected cells and probably modulates cytotoxicity of SARS-CoV-1 (Bhardwaj et al. 2012).

Referrals

(hasEvent)

[Pathway:R-HSA-9694686] Replication of the SARS-CoV-2 genome

(inferredTo)

[Reaction:R-HSA-9682712] nsp15 binds RB1

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