Reactome | nsp1-4 cleaves itself

Schema > Reaction > Entries

nsp1-4 cleaves itself Show undefined attributes

Go to Details

authored

[InstanceEdit:9698832] Stephan, Ralf, 2020年08月28日

catalystActivity

[CatalystActivity:9694586] cysteine-type endopeptidase activity of pp1a-nsp1-4 [cytosol]

category transition

compartment

[Compartment:70101] cytosol

created [InstanceEdit:9694660] Cook, Justin, 2020年07月07日

crossReference

[DatabaseIdentifier:11944893] Mondo:0100096

dbId 9694338

disease

[Disease:9683912] COVID-19

displayName nsp1-4 cleaves itself

edited

[InstanceEdit:9698832] Stephan, Ralf, 2020年08月28日

eventOf

[Pathway:R-HSA-9694301] Maturation of replicase proteins - Homo sapiens

followingEvent

inferredFrom

[Reaction:R-HSA-9684336] nsp1-4 cleaves itself - Homo sapiens

input

isChimeric false

isInDisease true

isInferred true

literatureReference

[LiteratureReference:9684306] Identification of severe acute respiratory syndrome coronavirus replicase products and characterization of papain-like protease activity

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

nsp1-4 cleaves itself

output

precedingEvent

relatedSpecies

[Species:9681683] Severe acute respiratory syndrome coronavirus 2

releaseDate 2020年09月15日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:9699044] Acencio, Marcio Luis, 2020年09月09日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-9694338

summation

[Summation:9694400] This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.

The papain-like protease domain of the nsp1-4 fragment alone is sufficient for processing the nsp1/2 and nsp2/3 cleavage sites (Harcourt et al, 2004).

Referrals

(hasEvent)

[Pathway:R-HSA-9694301] Maturation of replicase proteins

(precedingEvent)

(inferredTo)

[Reaction:R-HSA-9684336] nsp1-4 cleaves itself

Reactome Pathway Database

Reactome Pathway Database

nsp1-4 cleaves itself Show undefined attributes

Referrals

Cite Us!

Download As: