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Encapsidation of SARS coronavirus genomic RNA Show undefined attributes

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authored

[InstanceEdit:9696947] Rothfels, Karen, 2020年07月30日

category binding

compartment

created [InstanceEdit:9694660] Cook, Justin, 2020年07月07日

crossReference

[DatabaseIdentifier:11944893] Mondo:0100096

dbId 9694281

disease

[Disease:9683912] COVID-19

displayName Encapsidation of SARS coronavirus genomic RNA

edited

[InstanceEdit:9696947] Rothfels, Karen, 2020年07月30日

eventOf

[Pathway:R-HSA-9694322] Virion Assembly and Release - Homo sapiens

followingEvent

[Reaction:R-HSA-9694444] E and N are recruited to the M lattice - Homo sapiens

inferredFrom

[Reaction:R-HSA-9684234] Encapsidation of SARS coronavirus genomic RNA - Homo sapiens

input

isChimeric false

isInDisease true

isInferred true

literatureReference

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

Encapsidation of SARS coronavirus genomic RNA

output

[Complex:R-COV-9694612] encapsidated SARS-CoV-2 genomic RNA [endoplasmic reticulum-Golgi intermediate compartment membrane]

precedingEvent

relatedSpecies

[Species:9681683] Severe acute respiratory syndrome coronavirus 2

releaseDate 2020年09月15日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:9699044] Acencio, Marcio Luis, 2020年09月09日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-9694281

summation

[Summation:9694782] This COVID-19 event has been created by a combination of computational inference (see https://reactome.org/documentation/inferred-events) from SARS-CoV-1 data and manual curation, as described in the summation for the overall SARS-CoV-2 infection pathway.

Based on studies in other coronaviruses, the final SARS-COV-2 ribonucleoprotein complex is predicted to be a hollow helical structure with an approximate diameter of 9-16nm, with the C-terminal domain of N protein forming the inner core and the N-terminal domain forming the outer surface (Neuman et al, 2006; Chen et al, 2007). Oliomerization of the N protein capsid coat is likely nucleated through both protein-RNA and protein-protein interactions by the first few N-protein dimers on the genomic RNA (Saikatendu et al, 2007; Chang et al, 2013; reviewed in Chang et al, 2014). Each N dimer may make contact with up to 7 bases of the RNA (reviewed in Chang et al, 2014).

Referrals

(hasEvent)

[Pathway:R-HSA-9694322] Virion Assembly and Release

(precedingEvent)

[Reaction:R-HSA-9694444] E and N are recruited to the M lattice

(inferredTo)

[Reaction:R-HSA-9684234] Encapsidation of SARS coronavirus genomic RNA

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