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Schema
>
Reaction
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Entries
GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2)
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authored
[InstanceEdit:514615] D'Eustachio, P, 2010年02月17日
catalystActivity
[CatalystActivity:514632] GMP reductase activity of GMPR tetramers [cytosol]
catalystActivityReference
[CatalystActivityReference:9643147] GMP reductase activity of GMPR tetramers [cytosol] Reaction mechanism and specificity of human GMP reductase. Substrates, inhibitors, activators, and inactivators
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:514616] D'Eustachio, P, 2010年02月17日
crossReference
[DatabaseIdentifier:12610832] Rhea:17187
dbId
514604
displayName
GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2)
edited
[InstanceEdit:517475] D'Eustachio, P, 2010年02月18日
eventOf
[Pathway:R-HSA-74217] Purine salvage - Homo sapiens
input
[SimpleEntity:R-ALL-113578] GMP [cytosol]
[SimpleEntity:R-ALL-70106] H+ [cytosol]
[SimpleEntity:R-ALL-29364] NADPH [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:514607] NADPH-dependent GMP reductase isoenzyme of human (GMPR2). Expression, purification, and kinetic properties
[LiteratureReference:514622] Crystal structure of human guanosine monophosphate reductase 2 (GMPR2) in complex with GMP
[LiteratureReference:514627] Reaction mechanism and specificity of human GMP reductase. Substrates, inhibitors, activators, and inactivators
maxDepth
1
modified
[InstanceEdit:10867632] Weiser, Joel, 2025年08月27日
name
GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2)
orthologousEvent
[Reaction:R-MMU-514604] GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) - Mus musculus
[Reaction:R-CEL-514604] GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) - Caenorhabditis elegans
[Reaction:R-GGA-514604] GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) - Gallus gallus
[Reaction:R-XTR-514604] GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) - Xenopus tropicalis
[Reaction:R-DRE-514604] GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) - Danio rerio
[Reaction:R-SSC-514604] GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) - Sus scrofa
[Reaction:R-BTA-514604] GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) - Bos taurus
[Reaction:R-CFA-514604] GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) - Canis familiaris
[Reaction:R-RNO-514604] GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) - Rattus norvegicus
output
[SimpleEntity:R-ALL-29602] IMP [cytosol]
[SimpleEntity:R-ALL-29366] NADP+ [cytosol]
[SimpleEntity:R-ALL-31633] NH4+ [cytosol]
precedingEvent
[Reaction:R-HSA-74215] HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP - Homo sapiens
releaseDate
2010年03月16日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:165071] Graves, L, Rush, MG, 0000-00-00 00:00:00
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-514604
summation
[Summation:514623] Cytosolic GMP reductase (GMPR) catalyzes the reaction of GMP...
Referrals
(hasEvent)
[Pathway:R-HSA-74217] Purine salvage
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