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Interconversion of nucleotide di- and triphosphates
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authored
[InstanceEdit:504064] D'Eustachio, P, 2010年02月05日
compartment
[Compartment:70101] cytosol
[Compartment:17927] mitochondrial intermembrane space
[Compartment:7660] nucleoplasm
[Compartment:70616] mitochondrial inner membrane
[Compartment:5460] mitochondrial matrix
created
[InstanceEdit:499929] D'Eustachio, P, 2010年01月29日
dbId
499943
deleted
[Deleted:8959453] Deletion of instance: 73848
[Deleted:499951] Deletion of instance: 111748
[Deleted:500095] Deletion of instance: 110097
[Deleted:8959451] Deletion of instance: 73847
displayName
Interconversion of nucleotide di- and triphosphates
edited
[InstanceEdit:504064] D'Eustachio, P, 2010年02月05日
eventOf
[Pathway:R-HSA-15869] Metabolism of nucleotides - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:12875] nucleobase-containing small molecule interconversion
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-74220] (d)AMP + ATP <=> (d)ADP + ADP (AK1) - Homo sapiens
[Reaction:R-HSA-110141] (d)ADP + ADP <=> (d)AMP + ATP (AK1) - Homo sapiens
[Reaction:R-HSA-110145] AMP + ATP <=> ADP + ADP [AK2] - Homo sapiens
[Reaction:R-HSA-110144] ADP + ADP <=> AMP + ATP [AK2] - Homo sapiens
[Reaction:R-HSA-110138] AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs - Homo sapiens
[Reaction:R-HSA-110137] (d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP - Homo sapiens
[Reaction:R-HSA-6788798] AK4 phosphorylates (d)NMPs to (d)NDPs - Homo sapiens
[Reaction:R-HSA-6788810] AK6 phosphorylates (d)NMPs to (d)NDPs - Homo sapiens
[Reaction:R-HSA-73788] (d)GMP + ATP <=> (d)GDP + ADP (GUK1) - Homo sapiens
[Reaction:R-HSA-110133] (d)GDP + ADP <=> (d)GMP + ATP (GUK1) - Homo sapiens
[Reaction:R-HSA-73548] (d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) - Homo sapiens
[Reaction:R-HSA-75125] (d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP (CMPK1) - Homo sapiens
[Reaction:R-HSA-73635] dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] - Homo sapiens
[Reaction:R-HSA-75126] dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK] - Homo sapiens
[Reaction:R-HSA-73647] UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS] - Homo sapiens
[Reaction:R-HSA-504054] UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2] - Homo sapiens
[Reaction:R-HSA-111742] RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) - Homo sapiens
[Reaction:R-HSA-111751] RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) - Homo sapiens
[Reaction:R-HSA-8866405] RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) - Homo sapiens
[Reaction:R-HSA-111804] RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) - Homo sapiens
[Reaction:R-HSA-111746] glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized) - Homo sapiens
[Reaction:R-HSA-71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - Homo sapiens
[Reaction:R-HSA-73646] thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ - Homo sapiens
[Reaction:R-HSA-482619] (d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3) - Homo sapiens
[Reaction:R-HSA-482621] (d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3) - Homo sapiens
[Reaction:R-HSA-482804] (d)NDP + ATP <=> (d)NTP + ADP (NME4) - Homo sapiens
[Reaction:R-HSA-482812] (d)NTP + ADP <=> (d)NDP + ATP (NME4) - Homo sapiens
[Reaction:R-HSA-6786257] DCTPP1 hydrolyses 5idCTP - Homo sapiens
[Reaction:R-HSA-6810472] NUDT13 hydrolyses AP6A to AP4 and ADP - Homo sapiens
[Reaction:R-HSA-6806877] NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs - Homo sapiens
[Reaction:R-HSA-73596] dCMP + H2O => dUMP + NH4+ - Homo sapiens
[Reaction:R-HSA-73666] dUTP + H2O => dUMP + pyrophosphate - Homo sapiens
[Reaction:R-HSA-73605] dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2021年09月15日
literatureReference
[Book:110098] The Enzymes, 3rd ed Boyer, PD Nucleoside and nucleotide kinases 0121227022
[LiteratureReference:110100] Studies on the properties and tissue distribution of the isozymes of guanylate kinase in man
[Book:110077] The Enzymes, 3rd ed Boyer, PD Adenylate kinase 0121227022
[LiteratureReference:110102] Phosphorylation of nucleosides and nucleoside analogs by mammalian nucleoside monophosphate kinases
[LiteratureReference:110079] Adenylate kinases in man: evidence for a third locus
maxDepth
2
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
Interconversion of nucleotide di- and triphosphates
orthologousEvent
[Pathway:R-MMU-499943] Interconversion of nucleotide di- and triphosphates - Mus musculus
[Pathway:R-PFA-499943] Interconversion of nucleotide di- and triphosphates - Plasmodium falciparum
[Pathway:R-SCE-499943] Interconversion of nucleotide di- and triphosphates - Saccharomyces cerevisiae
[Pathway:R-SPO-499943] Interconversion of nucleotide di- and triphosphates - Schizosaccharomyces pombe
[Pathway:R-DDI-499943] Interconversion of nucleotide di- and triphosphates - Dictyostelium discoideum
[Pathway:R-CEL-499943] Interconversion of nucleotide di- and triphosphates - Caenorhabditis elegans
[Pathway:R-DME-499943] Interconversion of nucleotide di- and triphosphates - Drosophila melanogaster
[Pathway:R-GGA-499943] Interconversion of nucleotide di- and triphosphates - Gallus gallus
[Pathway:R-XTR-499943] Interconversion of nucleotide di- and triphosphates - Xenopus tropicalis
[Pathway:R-DRE-499943] Interconversion of nucleotide di- and triphosphates - Danio rerio
[Pathway:R-RNO-499943] Interconversion of nucleotide di- and triphosphates - Rattus norvegicus
[Pathway:R-CFA-499943] Interconversion of nucleotide di- and triphosphates - Canis familiaris
[Pathway:R-BTA-499943] Interconversion of nucleotide di- and triphosphates - Bos taurus
[Pathway:R-SSC-499943] Interconversion of nucleotide di- and triphosphates - Sus scrofa
releaseDate
2010年03月16日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:165071] Graves, L, Rush, MG, 0000-00-00 00:00:00
revised
[InstanceEdit:8956493] D'Eustachio, Peter, 2017年01月23日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-499943
summation
[Summation:110103] An array of kinases catalyze the reversible phosphorylation ...
updateTrackers
[UpdateTracker:9787039] Update Tracker - [Pathway:499943] Interconversion of nucleotide di- and triphosphates - v46:[updateContainedRLE]
[UpdateTracker:9790135] Update Tracker - [Pathway:499943] Interconversion of nucleotide di- and triphosphates - v35:[updateContainedRLE]
[UpdateTracker:9775693] Update Tracker - [Pathway:499943] Interconversion of nucleotide di- and triphosphates - v78:[updateContainedRLE]
[UpdateTracker:9783439] Update Tracker - [Pathway:499943] Interconversion of nucleotide di- and triphosphates - v56:[addHasEvent]
[UpdateTracker:9783285] Update Tracker - [Pathway:499943] Interconversion of nucleotide di- and triphosphates - v57:[add_removeHasEvent, updateContainedRLE]
[UpdateTracker:9781669] Update Tracker - [Pathway:499943] Interconversion of nucleotide di- and triphosphates - v60:[addHasEvent, updateContainedRLE]
[UpdateTracker:9779444] Update Tracker - [Pathway:499943] Interconversion of nucleotide di- and triphosphates - v65:[updateContainedRLE]
[UpdateTracker:9783822] Update Tracker - [Pathway:499943] Interconversion of nucleotide di- and triphosphates - v55:[addHasEvent]
[UpdateTracker:9784464] Update Tracker - [Pathway:499943] Interconversion of nucleotide di- and triphosphates - v54:[updateContainedRLE]
Referrals
(hasEvent)
[Pathway:R-HSA-15869] Metabolism of nucleotides
(replacementInstances)
[Deleted:8959453] Deletion of instance: 73848
[Deleted:499951] Deletion of instance: 111748
[Deleted:500095] Deletion of instance: 110097
[Deleted:8959451] Deletion of instance: 73847
(updatedInstance)
[UpdateTracker:9787039] Update Tracker - [Pathway:499943] Interconversion of nucleotide di- and triphosphates - v46:[updateContainedRLE]
[UpdateTracker:9790135] Update Tracker - [Pathway:499943] Interconversion of nucleotide di- and triphosphates - v35:[updateContainedRLE]
[UpdateTracker:9775693] Update Tracker - [Pathway:499943] Interconversion of nucleotide di- and triphosphates - v78:[updateContainedRLE]
[UpdateTracker:9783439] Update Tracker - [Pathway:499943] Interconversion of nucleotide di- and triphosphates - v56:[addHasEvent]
[UpdateTracker:9783285] Update Tracker - [Pathway:499943] Interconversion of nucleotide di- and triphosphates - v57:[add_removeHasEvent, updateContainedRLE]
[UpdateTracker:9781669] Update Tracker - [Pathway:499943] Interconversion of nucleotide di- and triphosphates - v60:[addHasEvent, updateContainedRLE]
[UpdateTracker:9779444] Update Tracker - [Pathway:499943] Interconversion of nucleotide di- and triphosphates - v65:[updateContainedRLE]
[UpdateTracker:9783822] Update Tracker - [Pathway:499943] Interconversion of nucleotide di- and triphosphates - v55:[addHasEvent]
[UpdateTracker:9784464] Update Tracker - [Pathway:499943] Interconversion of nucleotide di- and triphosphates - v54:[updateContainedRLE]
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