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FGFR1c P252X mutants bind ligand with enhanced affinity Show undefined attributes

authored

[InstanceEdit:2105031] Rothfels, K, 2012年02月09日

category binding

compartment

created [InstanceEdit:2023452] Rothfels, K, 2011年12月07日

crossReference

[DatabaseIdentifier:11944892] Mondo:0004992

dbId 2023451

disease

[Disease:1500689] cancer

displayName FGFR1c P252X mutants bind ligand with enhanced affinity

edited

[InstanceEdit:2252592] Rothfels, K, 2012年05月16日

entityFunctionalStatus

[EntityFunctionalStatus:5654502] gain_of_function of FGFR1c P252X mutants [plasma membrane]

eventOf

[Pathway:R-HSA-1839122] Signaling by activated point mutants of FGFR1 - Homo sapiens

followingEvent

[Reaction:R-HSA-2023455] Autocatalytic phosphorylation of FGFR1c P252X mutant dimers - Homo sapiens

input

isChimeric false

isInDisease true

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

FGFR1c P252X mutants bind ligand with enhanced affinity

normalReaction [Reaction:R-HSA-190256] FGFR1c binds to FGF

output

[Complex:R-HSA-2050638] FGFR1c P252X mutant dimers bound to FGFs [plasma membrane]

releaseDate 2012年06月12日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:2248845] Ezzat, S, 2012年05月15日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-2023451

summation

[Summation:2023406] The missense mutation C775G in exon 5 of FGFR1 encodes a Pro...

Referrals

(hasEvent)

[Pathway:R-HSA-1839122] Signaling by activated point mutants of FGFR1

(precedingEvent)

[Reaction:R-HSA-2023455] Autocatalytic phosphorylation of FGFR1c P252X mutant dimers

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