Reactome Pathway Database

Schema > EntityWithAccessionedSequence > Entries

HSPG2(22-4391) [extracellular region] Show undefined attributes

compartment

[Compartment:984] extracellular region

componentOf

[Complex:R-HSA-2426324] HSPG2:Dystroglycan [plasma membrane] - Homo sapiens
[Complex:R-HSA-4084512] Laminins with alpha-1, -2 or -5:HSPG2(22-4391) [extracellular region] - Homo sapiens
[Complex:R-HSA-977084] Amyloid fibrils [plasma membrane] - Homo sapiens

consumedByEvent

[Reaction:R-HSA-2396395] HSPG2 (perlecan) binds alpha-dystroglycan - Homo sapiens
[Reaction:R-HSA-2396337] HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer - Homo sapiens
[Reaction:R-NUL-2534170] Degradation of HSPG2 by Mmp13 and Ctss - Homo sapiens
[Reaction:R-HSA-2534160] HSPG2 (perlecan) degradation by MMP13, CTSS - Homo sapiens
[Reaction:R-HSA-1592314] HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) - Homo sapiens
[Reaction:R-HSA-3814820] HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 - Homo sapiens
[Reaction:R-HSA-2534240] HSPG2 (perlecan) degradation by MMP14, MMP15 - Homo sapiens
[Reaction:R-HSA-2426530] Laminins:Nidogens binds HSPG2 - Homo sapiens
[Reaction:R-HSA-4084505] Laminins bind HSPG2 - Homo sapiens
[Reaction:R-HSA-976734] Amyloid fibrils have additional components - Homo sapiens

created [InstanceEdit:1011571] Jupe, S, 2010年11月11日

dbId 1011570

displayName HSPG2(22-4391) [extracellular region]

endCoordinate 4391

inDisease false

inferredTo

maxDepth 1

memberOf

[DefinedSet:R-HSA-2426293] AGRN, HSPG2 [extracellular region] - Homo sapiens

modified [InstanceEdit:3632907] Wu, G, 2013年05月28日

name

HSPG2(22-4391)
HSPG2
Perlecan
Basement membrane-specific heparan sulfate proteoglycan core protein

referenceEntity [ReferenceGeneProduct:uniprot:P98160] UniProt:P98160 HSPG2

referenceType ReferenceGeneProduct

schemaClass EntityWithAccessionedSequence

species [Species:48887] Homo sapiens

stId R-HSA-1011570

startCoordinate 22

updateTrackers

Referrals

(updatedInstance)

(hasComponent)

(input)

(hasMember)

[DefinedSet:R-HSA-2426293] AGRN, HSPG2 [extracellular region]

© 2025 Reactome

Cite Us!