TAS-108
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| Other names | 17β-[2-[4-[(diethylamino)methyl]-2-methoxyphenoxy]ethyl]-7α-methylestra-1,3,5(10)-trien-3-ol; 17β-[2-[4-[(diethylamino)methyl]-2-methoxyphenoxy]ethyl]-7α-methylestradiol |
| Routes of administration | By mouth [1] |
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| Formula | C33H47NO3 |
| Molar mass | 505.743 g·mol−1 |
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TAS-108, also known as SR-16234, is a drug discovered by Masato Tanabe and under development by SRI International and Taiho Pharmaceutical. It is a steroid hormone that has shown signs of treating and preventing breast cancer, even in patients where tamoxifen has failed.[2] [3]
Development
[edit ]Masato Tanabe's team at SRI has focused on the development of steroid hormones. A compound discovered in a previous SRI contract from the National Institutes of Health showed potential – it acted like "anti-estrogen" in the breasts and uterus but like normal estrogen elsewhere in the body, and was more "tissue-selective".[4] A contract was proposed to Taiho Pharmaceutical in July 1996, and within six years and slightly under 3ドル million (an unusually short amount of time), two new drugs were discovered and tested on people (particularly people for which tamoxifen has failed): SR-16234 and SR-16287.[4]
The first of those, SR-16234, also inhibited the growth of blood vessels angiogenesis and accelerated the death of cancer cells apoptosis and thus was particularly well suited to be an anti-cancer drug.[4] As of August 2010, the drug had been through five Phase I and two Phase II studies,[5] and Phase III studies are being planned.[6]
See also
[edit ]References
[edit ]- ^ Yamamoto Y, Shibata J, Yonekura K, Sato K, Hashimoto A, Aoyagi Y, et al. (January 2005). "TAS-108, a novel oral steroidal antiestrogenic agent, is a pure antagonist on estrogen receptor alpha and a partial agonist on estrogen receptor beta with low uterotrophic effect". Clinical Cancer Research. 11 (1): 315–322. doi:10.1158/1078-0432.315.11.1. PMID 15671561.
- ^ Yamamoto Y, Wada O, Takada I, Yogiashi Y, Shibata J, Yanagisawa J, et al. (December 2003). "Both N- and C-terminal transactivation functions of DNA-bound ERalpha are blocked by a novel synthetic estrogen ligand". Biochemical and Biophysical Research Communications. 312 (3): 656–662. doi:10.1016/j.bbrc.2003年10月17日8. PMID 14680815.
- ^ "Alumni Hall of Fame 2004: Masato Tanabe". SRI International. Archived from the original on 2013年01月04日. Retrieved 2013年02月10日.
- ^ a b c Nielson D (2006). A Heritage of Innovation: SRI's First Half Century. Menlo Park, California: SRI International. pp. 10–15. ISBN 978-0-9745208-1-0.
- ^ "SRI International to Advance Clinical Development of TAS-108, a Late-Stage Breast Cancer Drug" (Press release). SRI International. Archived from the original on 2013年04月03日. Retrieved 2013年02月24日.
- ^ Buzdar AU (January 2005). "TAS-108: a novel steroidal antiestrogen". Clinical Cancer Research. 11 (2 Pt 2): 906s – 908s. doi:10.1158/1078-0432.906s.11.2 . PMID 15701885.
External links
[edit ]- SR-16234 (TAS-108) - AdisInsight
- TS 108 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)