Pethidine intermediate A
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Chemical compound
Pharmaceutical compound
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| Routes of administration | N/A |
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| ECHA InfoCard | 100.020.771 Edit this at Wikidata |
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| Formula | C13H16N2 |
| Molar mass | 200.285 g·mol−1 |
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Pethidine intermediate A is a four-phenyl piperidine derivative that is a precursor to the opioid analgesic drug pethidine (meperidine). It is not known to have any analgesic activity in its own right, however other derivatives of pethidine with a 4-cyano group in place of the carboxylate ethyl ester have been found to be active,[2] so pethidine intermediate A might also show opioid effects. It is scheduled by UN Single Convention on Narcotic Drugs. It is a Schedule II Narcotic controlled substance in the United States and has an ACSCN of 9232. The 2014 annual manufacturing quota was 6 grammes (as an end product, presumably for research use).[3]
See also
[edit ]- Moramide intermediate
- Methadone intermediate
- Pethidine intermediate B (norpethidine)
- Pethidine intermediate C (pethidinic acid)
References
[edit ]- ^ Anvisa (2023年03月31日). "RDC No 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023年04月04日). Archived from the original on 2023年08月03日. Retrieved 2023年08月16日.
- ^ Lomenzo SA, Rhoden JB, Izenwasser S, Wade D, Kopajtic T, Katz JL, Trudell ML (March 2005). "Synthesis and biological evaluation of meperidine analogues at monoamine transporters". Journal of Medicinal Chemistry. 48 (5): 1336–43. doi:10.1021/jm0401614. PMID 15743177.
- ^ "Conversion Factors for Controlled Substances". Diversion Control Division. Drug Enforcement Agency, U.S. Department of Justice.