Jump to content
Wikipedia The Free Encyclopedia

Nitecapone

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Nitecapone
Skeletal formula
Space-filling model
Clinical data
ATC code
  • None
Identifiers
  • 3-[(3,4-Dihydroxy-5-nitrophenyl)methylidene]pentane-2,4-dione
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
Formula C12H11NO6
Molar mass 265.221 g·mol−1
3D model (JSmol)
  • [O-][N+](=O)c1cc(\C=C(/C(=O)C)C(=O)C)cc(O)c1O
  • InChI=1S/C12H11NO6/c1-6(14)9(7(2)15)3-8-4-10(13(18)19)12(17)11(16)5-8/h3-5,16-17H,1-2H3
  • Key:UPMRZALMHVUCIN-UHFFFAOYSA-N

Nitecapone (INN; OR-462) is a drug which acts as a selective inhibitor of the enzyme catechol O-methyl transferase (COMT).[1] [2] It was patented as an antiparkinson medication but was never marketed.[1]

See also

[edit ]

References

[edit ]
  1. ^ a b F.. Macdonald (1997). Dictionary of Pharmacological Agents. CRC Press. p. 1635. ISBN 978-0-412-46630-4 . Retrieved 20 May 2012.
  2. ^ Nissinen E, Lindén IB, Schultz E, Kaakkola S, Männistö PT, Pohto P (August 1988). "Inhibition of catechol-O-methyltransferase activity by two novel disubstituted catechols in the rat". European Journal of Pharmacology. 153 (2–3): 263–9. doi:10.1016/0014-2999(88)90614-0. PMID 3181288.
Dopaminergics
DA precursors
DA receptor agonists
MAO-B inhibitors
COMT inhibitors
AAAD inhibitors
Anticholinergics
Others
Non-specific
AAAD Tooltip Aromatic L-amino acid decarboxylase
MAO Tooltip Monoamine oxidase
Phenethylamines
(dopamine, epinephrine,
norepinephrine)
PAH Tooltip Phenylalanine hydroxylase
TH Tooltip Tyrosine hydroxylase
DBH Tooltip Dopamine beta-hydroxylase
PNMT Tooltip Phenylethanolamine N-methyltransferase
COMT Tooltip Catechol-O-methyl transferase
Tryptamines
(serotonin, melatonin)
TPH Tooltip Tryptophan hydroxylase
AANAT Tooltip Serotonin N-acetyl transferase
ASMT Tooltip Acetylserotonin O-methyltransferase
Histamine
HDC Tooltip Histidine decarboxylase
HNMT Tooltip Histamine N-methyltransferase
DAO Tooltip Diamine oxidase
Stub icon

This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.

AltStyle によって変換されたページ (->オリジナル) /