ITPKB

Protein-coding gene in the species Homo sapiens

ITPKB

Identifiers

ITPKB , IP3-3KB, IP3K, IP3K-B, IP3KB, PIG37, inositol-trisphosphate 3-kinase B

External IDs

OMIM: 147522; MGI: 109235; HomoloGene: 1672; GeneCards: ITPKB; OMA:ITPKB - orthologs

Gene location (Human)
Chromosome 1 (human)
Chr.	Chromosome 1 (human) ^[1]
Chromosome 1 (human) Genomic location for ITPKB Genomic location for ITPKB
Band	1q42.12	Start	226,631,690 bp ^[1]
Band	1q42.12	End	226,739,323 bp ^[1]

Gene location (Mouse)
Chromosome 1 (mouse)
Chr.	Chromosome 1 (mouse)^[2]
Chromosome 1 (mouse) Genomic location for ITPKB Genomic location for ITPKB
Band	1 H4\|1 84.27 cM	Start	180,158,050 bp ^[2]
Band	1 H4\|1 84.27 cM	End	180,252,367 bp ^[2]

RNA expression pattern

Bgee

Human	Mouse (ortholog)
Top expressed in external globus pallidus pars reticulata dorsal motor nucleus of vagus nerve internal globus pallidus inferior olivary nucleus pars compacta subthalamic nucleus ventral tegmental area superior vestibular nucleus middle frontal gyrus	Top expressed in choroid plexus of fourth ventricle lactiferous gland sciatic nerve islet of Langerhans right lung internal carotid artery blood thymus left lung right lung lobe
More reference expression data

BioGPS

More reference expression data

Gene ontology
Molecular function	transferase activity nucleotide binding calmodulin binding kinase activity protein binding ATP binding inositol-1,4,5-trisphosphate 3-kinase activity
Cellular component	cytosol membrane nucleus
Biological process	regulation of protein phosphorylation cellular response to calcium ion negative regulation of neutrophil apoptotic process phosphorylation common myeloid progenitor cell proliferation myeloid cell homeostasis positive regulation of Ras protein signal transduction inositol phosphate metabolic process inositol trisphosphate metabolic process MAPK cascade cell surface receptor signaling pathway T cell differentiation positive thymic T cell selection negative regulation of myeloid cell differentiation positive regulation of alpha-beta T cell differentiation thymic T cell selection signal transduction inositol phosphate biosynthetic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3707


320404

Ensembl


ENSG00000143772


ENSMUSG00000038855

UniProt


P27987


B2RXC2

RefSeq (mRNA)

NM_002221
NM_001388404

NM_001081175

RefSeq (protein)

NP_002212

NP_001074644

Location (UCSC)

Chr 1: 226.63 – 226.74 Mb

Chr 1: 180.16 – 180.25 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human View/Edit Mouse

Inositol-trisphosphate 3-kinase B is an enzyme that in humans is encoded by the ITPKB gene.^[5]^[6]

Function

[edit ]

The protein encoded by the ITPKB gene is one of 3 isoforms of Inositol-trisphosphate 3-kinase expressed in humans. ITPKB protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate, which releases calcium from intracellular store in the endoplasmic reticulum by gating the inositol trisphosphate receptor. ITPKB produces Ins(1,3,4,5)P4, which does not gate the inositol trisphosphate receptor. The enzyme specifically phosphorylates the 1,4,5 isomer of IP3. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity.^[7] Itpkb regulates immune cell function and is required for T and B cell development.^[8]

References

[edit ]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143772 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038855 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Takazawa K, Perret J, Dumont JE, Erneux C (Oct 1991). "Molecular cloning and expression of a new putative inositol 1,4,5-trisphosphate 3-kinase isoenzyme". Biochem J. 278 (3): 883–6. doi:10.1042/bj2780883. PMC 1151429 . PMID 1654894.
^ Erneux C, Roeckel N, Takazawa K, Mailleux P, Vassart G, Mattei MG (Dec 1992). "Localization of the genes for human inositol 1,4,5-trisphosphate 3-kinase A (ITPKA) and B (ITPKB) to chromosome regions 15q14-q21 and 1q41-q43, respectively, by in situ hybridization". Genomics. 14 (2): 546–7. doi:10.1016/S0888-7543(05)80265-4. PMID 1330886.
^ "Entrez Gene: ITPKB inositol 1,4,5-trisphosphate 3-kinase B".
^ Sauer K, Cooke MP (April 2010). "Regulation of immune cell development through soluble inositol-1,3,4,5-tetrakisphosphate". Nat. Rev. Immunol. 10 (4): 257–71. doi:10.1038/nri2745. PMC 2922113 . PMID 20336153.

Function

References

Further reading