GPR137B

Mammalian protein found in Homo sapiens

GPR137B

Identifiers

GPR137B , TM7SF1, G protein-coupled receptor 137B

External IDs

OMIM: 604658; MGI: 1891463; HomoloGene: 2454; GeneCards: GPR137B; OMA:GPR137B - orthologs

Gene location (Human)
Chromosome 1 (human)
Chr.	Chromosome 1 (human) ^[1]
Chromosome 1 (human) Genomic location for GPR137B Genomic location for GPR137B
Band	1q42.3	Start	236,142,505 bp ^[1]
Band	1q42.3	End	236,221,865 bp ^[1]

Gene location (Mouse)
Chromosome 13 (mouse)
Chr.	Chromosome 13 (mouse)^[2]
Chromosome 13 (mouse) Genomic location for GPR137B Genomic location for GPR137B
Band	13 A1\|13 5.24 cM	Start	13,532,205 bp ^[2]
Band	13 A1\|13 5.24 cM	End	13,568,599 bp ^[2]

RNA expression pattern

Bgee

Human	Mouse (ortholog)
Top expressed in retinal pigment epithelium trigeminal ganglion internal globus pallidus oocyte corpus epididymis kidney tubule spinal ganglia secondary oocyte nucleus accumbens caudate nucleus	Top expressed in right kidney morula lens epithelium of lens proximal tubule sciatic nerve calvaria blastocyst human kidney granulocyte
More reference expression data

BioGPS

n/a

Orthologs

Species

Human

Mouse

Entrez


7107


83924

Ensembl


ENSG00000077585


ENSMUSG00000021306

UniProt


O60478


Q8BNQ3

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1: 236.14 – 236.22 Mb

Chr 13: 13.53 – 13.57 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human View/Edit Mouse

G protein-coupled receptor 137B also known as GPR137B is a G protein-coupled receptor which in humans is encoded by the GPR137B gene.^[5] The expression of GPR137B is upregulated during kidney development.

References

[edit ]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000077585 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021306 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Spangenberg C, Winterpacht A, Zabel BU, Löbbert RW (March 1998). "Cloning and characterization of a novel gene (TM7SF1) encoding a putative seven-pass transmembrane protein that is upregulated during kidney development". Genomics. 48 (2): 178–85. doi:10.1006/geno.1997.5170. PMID 9521871.

v
t
e

Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but 5-HT3) 5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2), EP (1 2 3 4), FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2, GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Anaphylatoxin (C3a
C5a (1
2))
Angiotensin (1
2)
Apelin
Bombesin
- BRS3
- GRPR
- NMBR)
- Bradykinin (B1
- B2)
Chemerin
- 1
- 2
Chemokine
Cholecystokinin (A
B)
Endothelin
- A
- B
Formyl peptide (1
2
3)
FSH
Galanin (1
2
3)
Gonadotropin-releasing hormone (1
2)
Ghrelin
Kisspeptin
Luteinizing hormone/choriogonadotropin
MAS (1
1L
D
E
F
G
X1
X2
X3
X4)
Melanocortin (1
2
3
4
5)
MCHR (1
2)
Motilin
Opioid (Delta
Kappa
Mu
Nociceptin & Zeta, but not Sigma)
Orexin (1
2)
Oxytocin
Prokineticin (1
2)
Prolactin-releasing peptide
Relaxin (1
2
3
4)
Somatostatin (1
2
3
4
5)
Tachykinin (1
2
3)
Thyrotropin
Thyrotropin-releasing hormone
Urotensin-II
Vasopressin (1A
1B
2)

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR (3 4 6 12 15 17 18 19 20 21 22 26 27 31 32 33 34 35 37 39 42 45 50 52 55 61 62 63 65 68 75 78 82 83 84 85 87 88 101 103 109A 119 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B: Secretin-like

Adhesion	ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRE EMR 1 2 3 CD97 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 ELTD1
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Calcitonin CALCRL Corticotropin-releasing hormone (1 2) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C: Metabotropic glutamate / pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)