Jump to content
Wikipedia The Free Encyclopedia

CHRNA6

From Wikipedia, the free encyclopedia
Protein-coding gene in humans
CHRNA6
Identifiers
Aliases CHRNA6 , CHNRA6, cholinergic receptor nicotinic alpha 6 subunit
External IDsOMIM: 606888; MGI: 106213; HomoloGene: 20888; GeneCards: CHRNA6; OMA:CHRNA6 - orthologs
Gene location (Human)
Chromosome 8 (human)
Chr. Chromosome 8 (human) [1]
Band 8p11.21Start42,752,620 bp [1]
End42,796,392 bp [1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr. Chromosome 8 (mouse)[2]
Band 8|8 A2Start27,893,240 bp [2]
End27,903,972 bp [2]
RNA expression pattern
Bgee
Human Mouse (ortholog)
Top expressed in
  • testicle

  • tibialis anterior muscle

  • mucosa of ileum

  • gonad

  • cerebellar cortex

  • deltoid muscle

  • cerebellar hemisphere

  • prefrontal cortex

  • right hemisphere of cerebellum

  • substantia nigra
Top expressed in
  • lumbar spinal ganglion

  • neural layer of retina

  • substantia nigra

  • ventral tegmental area

  • blastocyst

  • central gray substance of midbrain

  • Ileal epithelium

  • superior colliculus

  • pituitary gland

  • embryo
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8973

11440

Ensembl

ENSG00000147434

ENSMUSG00000031491

UniProt

Q15825

Q9R0W9

RefSeq (mRNA)

NM_004198
NM_001199279

NM_021369

RefSeq (protein)

NP_001186208
NP_004189

NP_067344

Location (UCSC)Chr 8: 42.75 – 42.8 Mb Chr 8: 27.89 – 27.9 Mb
PubMed search[3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cholinergic receptor, nicotinic, alpha 6, also known as nAChRα6, is a protein that in humans is encoded by the CHRNA6 gene.[5] The CHRNA6 gene codes for the α6 nicotinic receptor subunit that is found in certain types of nicotinic acetylcholine receptors found primarily in the brain.

Tissue distribution

[edit ]

α6-containing nicotinic acetylcholine receptors (nAChRs) show a restricted expression pattern in the brain. Neural nicotinic acetylcholine receptors containing α6 subunits are expressed on dopamine-releasing neurons in the midbrain.[6] [7]

Function

[edit ]

These receptors play a key role in regulating dopaminergic neurotransmission. Dopamine release following activation of these neurons is thought to be involved in the addictive properties of nicotine.[8] [9] [10] In addition to nicotine, research in animals has implicated α6-containing nAChRs in the abusive and addictive properties of ethanol, with mecamylamine demonstrating a potent ability to block these properties.

Clinical significance

[edit ]

Because of their selective distribution and role in dopamine regulation, α6-containing receptors have been investigated as therapeutic targets. Due to their selective localisation on dopaminergic neurons, α6-containing nACh receptors have also been suggested as a possible therapeutic target for the treatment of Parkinson's disease.[11] [12]

Interactive pathway map

[edit ]

Click on genes, proteins and metabolites below to link to respective articles.[§ 1]

[[File:
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
|alt=Nicotine Activity on Dopaminergic Neurons edit]]
Nicotine Activity on Dopaminergic Neurons edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".

See also

[edit ]

References

[edit ]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000147434 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031491 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: CHRNA6 cholinergic receptor, nicotinic, alpha 6".
  6. ^ Le Novère N, Zoli M, Changeux JP (November 1996). "Neuronal nicotinic receptor alpha 6 subunit mRNA is selectively concentrated in catecholaminergic nuclei of the rat brain". The European Journal of Neuroscience. 8 (11): 2428–2439. doi:10.1111/j.1460-9568.1996.tb01206.x. PMID 8950106. S2CID 23102912.
  7. ^ Meyer EL, Yoshikami D, McIntosh JM (June 2008). "The neuronal nicotinic acetylcholine receptors alpha 4* and alpha 6* differentially modulate dopamine release in mouse striatal slices". Journal of Neurochemistry. 105 (5): 1761–1769. doi:10.1111/j.1471-4159.2008.05266.x. PMC 2527994 . PMID 18248619.
  8. ^ Calabresi P, Di Filippo M (October 2008). "ACh/dopamine crosstalk in motor control and reward: a crucial role for alpha 6-containing nicotinic receptors?". Neuron. 60 (1): 4–7. doi:10.1016/j.neuron.2008年09月03日1 . PMID 18940582. S2CID 10537163.
  9. ^ Drenan RM, Grady SR, Whiteaker P, McClure-Begley T, McKinney S, Miwa JM, et al. (October 2008). "In vivo activation of midbrain dopamine neurons via sensitized, high-affinity alpha 6 nicotinic acetylcholine receptors". Neuron. 60 (1): 123–136. doi:10.1016/j.neuron.200809009. PMC 2632732 . PMID 18940593.
  10. ^ Exley R, Clements MA, Hartung H, McIntosh JM, Cragg SJ (August 2008). "Alpha6-containing nicotinic acetylcholine receptors dominate the nicotine control of dopamine neurotransmission in nucleus accumbens". Neuropsychopharmacology. 33 (9): 2158–2166. doi:10.1038/sj.npp.1301617 . PMID 18033235.
  11. ^ Quik M, McIntosh JM (February 2006). "Striatal alpha6* nicotinic acetylcholine receptors: potential targets for Parkinson's disease therapy". The Journal of Pharmacology and Experimental Therapeutics. 316 (2): 481–489. doi:10.1124/jpet.105.094375. PMID 16210393. S2CID 20050682.
  12. ^ Bordia T, Grady SR, McIntosh JM, Quik M (July 2007). "Nigrostriatal damage preferentially decreases a subpopulation of alpha6beta2* nAChRs in mouse, monkey, and Parkinson's disease striatum". Molecular Pharmacology. 72 (1): 52–61. doi:10.1124/mol.107.035998. PMID 17409284. S2CID 25281990.

Further reading

[edit ]
[edit ]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Stub icon

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

AltStyle によって変換されたページ (->オリジナル) /