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Alclofenac

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Alclofenac
Clinical data
AHFS/Drugs.com International Drug Names
ATC code
Identifiers
  • 2-(3-chloro-4-prop-2-enoxyphenyl)acetic acid
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.040.709 Edit this at Wikidata
Chemical and physical data
Formula C11H11ClO3
Molar mass 226.66 g·mol−1
3D model (JSmol)
  • Clc1cc(ccc1OC\C=C)CC(=O)O
  • InChI=1S/C11H11ClO3/c1-2-5-15-10-4-3-8(6-9(10)12)7-11(13)14/h2-4,6H,1,5,7H2,(H,13,14) checkY
  • Key:ARHWPKZXBHOEEE-UHFFFAOYSA-N checkY
  (verify)

Alclofenac is a nonsteroidal anti-inflammatory drug (NSAID).

Synthesis

[edit ]
Alclofenac synthesis pathway[1] [2] [3]

References

[edit ]
  1. ^ Gaviraghi G, Banfi S, Cornelli U, Pinza M, Pifferi G (April 1977). "Synthesis and antiinflammatory activity of 3-chloro-4-cyclopropylmethoxyphenylacetic acid and its alpha-methyl homologue". Il Farmaco; Edizione Scientifica. 32 (4): 286–95. PMID 862882.
  2. ^ CA 831040, Gillet C, Buu HN, Lambelin G, "Substituted Phenylacetic Acids and Processes of Preparation Thereof", published 30 December 1969, assigned to Madan Ag 
  3. ^ US 3824277, Gillet C, Buu HN, Lambelin G, "4-Allyloxy-3-chloro-phenyl-acetic acid", published 16 July 1974, assigned to Madan Ag 
Non-steroidal anti-inflammatory drugs (NSAIDs) (primarily M01A and M02A, also N02BA)
pyrazolones /
pyrazolidines
salicylates
acetic acid derivatives
and related substances
oxicams
propionic acid
derivatives (profens)
n-arylanthranilic
acids (fenamates)
COX-2 inhibitors
(coxibs)
other
NSAID
combinations
Key: underline indicates initially developed first-in-class compound of specific group; #WHO-Essential Medicines; withdrawn drugs; veterinary use.
Receptor
(ligands)
DP (D2) Tooltip Prostaglandin D2 receptor
DP1 Tooltip Prostaglandin D2 receptor 1
DP2 Tooltip Prostaglandin D2 receptor 2
EP (E2) Tooltip Prostaglandin E2 receptor
EP1 Tooltip Prostaglandin EP1 receptor
EP2 Tooltip Prostaglandin EP2 receptor
EP3 Tooltip Prostaglandin EP3 receptor
EP4 Tooltip Prostaglandin EP4 receptor
Unsorted
FP (F) Tooltip Prostaglandin F receptor
IP (I2) Tooltip Prostacyclin receptor
TP (TXA2) Tooltip Thromboxane receptor
Unsorted
Enzyme
(inhibitors)
COX
(PTGS)
PGD2S Tooltip Prostaglandin D synthase
PGES Tooltip Prostaglandin E synthase
PGFS Tooltip Prostaglandin F synthase
PGI2S Tooltip Prostacyclin synthase
TXAS Tooltip Thromboxane A synthase
Others


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