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  1. Active pharmaceutical ingredients (APIs) have poor efficacy and low bloodstream and target site concentrations due to their limited water solubility. Pregabalin is essential product to control pain and inflamm...

    Authors: Yasir Mehmood, Syeda Momena Rizvi, Musarrat Ijaz, Tamseela Shahzadi, Hira Shahid, Shabbir Ahmed, Akhtar Rasul, Javed Iqbal, Abdulrahman A. Almehizia, Amir Bouallegue, Musaab Dauelbait and Esmael M. Alyami
    Citation: BMC Biotechnology 2025 25:126
    Content type: Research Published on:

  2. Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-based gene editing has become a promising approach for enhancing traits in aquaculture species. Nevertheless, traditional CRISPR-Cas systems e...

    Authors: Sheng Huang, Falin Zhou, Ziyi Jiang, Song Jiang, Qibin Yang, Lishi Yang, Jianhua Huang, Jianzhi Shi, Yangyang Ding, Erchao Li and Yundong Li
    Citation: BMC Biotechnology 2025 25:125
    Content type: Research Published on:

  3. Early-stage Luminal A breast cancer generally has a favorable prognosis, yet some patients experience recurrence, presenting a challenge in understanding the underlying genetic factors. This study aimed to ide...

    Authors: Kezhen Lv, Yongxia Chen, Jichun Zhou, Feiyang Ji and Wenxian Hu
    Citation: BMC Biotechnology 2025 25:124
    Content type: Research Published on:

  5. The present study focused on the antibacterial activity, mechanism and application of Pseudoduganella armeniaca ZMN − 3 extracellular polysaccharide nano silver. Extracellular polysaccharide nano silver was prepa...

    Authors: Yumeng Cui, Jiajun Ma, Guohui Gao, Xintong Duan, Ming Ying, Lei Huang and Meitong Li
    Citation: BMC Biotechnology 2025 25:122
    Content type: Research Published on:

  7. RNA degradation during freeze‒thaw cycles in cryopreserved tissues is a major challenge for biomedical research, particularly when tissues are stored without preservatives. While agents such as TRIzol and RNAL...

    Authors: Cong Zou, Mengxue Yu, Hongwei Peng, Xin Zhang, Zhao Deng, Zongning Zhou, Wenjing Li, Shanshan Zhang and Kaiyu Qian
    Citation: BMC Biotechnology 2025 25:120
    Content type: Research Published on:

  8. Adenovirus is one of the most attractive viral vectors for therapeutic vaccines and gene therapy with the caveat that replication-competent adenoviruses (RCA) can be produced. To remediate this problem, engine...

    Authors: Chun Fang Shen, Elodie Burney, Rénald Gilbert, Sonia Tremblay and Martin Loignon
    Citation: BMC Biotechnology 2025 25:119
    Content type: Research Published on:

  10. The escalating ecological pollution, particularly from organic colorants, is having a devastating impact on aquatic ecosystems, with dire consequences for marine life such as discharge of polluted water from v...

    Authors: Faiz Rabbani, Hafza Nosheen Anwar, Huzaifa Shahid, Faisal Faiz, M. Asim Farid, M. Atif, G. M. Shah, Hafiz Faiq Bakhat, Ahson J. Shaikh, M. Mubeen, M. Akram, Adnan Arshad, Hakkı Akdeniz, Zeki Erden, Çağdaş Can Toprak, Ayman El Sabagh…
    Citation: BMC Biotechnology 2025 25:117
    Content type: Research Published on:

  11. Mesenchymal stem cells (MSC) play a vital role in bone regeneration. Poly-(l-lactide-co-ε-caprolactone) scaffolds functionalised with modified rhamnogalacturonan-I (RG-I) potato pectin, can modulate inflammati...

    Authors: Amir Mukhtar, Athina Giannoudis, Bodil Jørgensen, Dongmei Wu, Xuan Liu, Kamal Babikeir Elnour Mustafa, Gudveig Cecilie Gjerde Gjengedal, Oluwatobi Adegbite, Anna Mieszkowska, Lu-Gang Yu and Katarzyna Gurzawska-Comis
    Citation: BMC Biotechnology 2025 25:115
    Content type: Research Published on:

  12. Collagen, the most abundant protein in the mammalian extracellular matrix, is critical for skin structure and function, with Type I and Type III collagens being particularly important. Collagen degradation in ...

    Authors: Wei Chen, Ning Wang, Xinshan Xie, Han Liu, Yiting Wang, Yanfeng Nie, Chun Chen, Huaiqing Sun, An Hong, Chaowan Guo and Sheng Xiong
    Citation: BMC Biotechnology 2025 25:116
    Content type: Research Published on:

  14. During the fermentation of small-leaved Kuding tea by Aspergillus cristatus, significant fluctuations in environmental osmotic pressure can affect the growth and metabolism of A. cristatus, thereby influencing th...

    Authors: Hang Zhou, Lu Yi Xie, Jiu Ping Hu, Li Hong Zhou, Ling Qing Lu, Yi Yang, Rong Rong Zhang, Yun Xue He and Ming Zheng Ren
    Citation: BMC Biotechnology 2025 25:113
    Content type: Research Published on:

  15. Foot-and-mouth disease (FMD), caused by foot-and-mouth disease virus (FMDV), is an acute, highly contagious, and economically devastating disease affecting cloven-hoofed animals worldwide. Vaccination remains ...

    Authors: Suling Zhang, Siyu Wu, Yan Liu, Xiaolin Geng, Yuxin Huang, Yanan Yue, He Yan, Peng Wu, Yurui Wang, Kegong Tian, Aihua Wang and Wenqiang Pang
    Citation: BMC Biotechnology 2025 25:112
    Content type: Research Published on:

  17. Forkhead box K1 (FOXK1) is a newly discovered gene encoding a transcription factor in the FOX family. It plays important roles in the cell cycle, cell growth, proliferation, differentiation, apoptosis, metabolism...

    Authors: He Long, Qinghua Hu, Lan Yang and Xin Li
    Citation: BMC Biotechnology 2025 25:110
    Content type: Research Published on:

  18. Decellularized tissues provide biological cues owing to the wealth of structural and regulatory factors that promote angiogenesis, adipogenesis, and myogenesis and facilitate neurite outgrowth. Here, we demons...

    Authors: Piejko Marcin, Hinz Alicja, Mak Paweł, Ligas Elwira, Misztal Krzysztof, Janowski Mirosław, Wałęga Piotr and Drukała Justyna
    Citation: BMC Biotechnology 2025 25:109
    Content type: Research Published on:

  19. Mercury (Hg) is a naturally occurring heavy metal with high toxicitythat affects various organs. This study aimed to evaluate the protective effects of N-acetylcysteine (NAC) on the lung tissue of Wistar rats ...

    Authors: Kebria Diako, Shadi Rahimi, Seyed Ali Mirbagheri Saghaleksari, Seyed Milad Mousavi Eshkelani, Niloofar Keshavarz Taramsari, Asghar Beigi Harchegani, Zhaleh Mohsenifar, Mahdi Shahriarinour and Najmeh Ranji
    Citation: BMC Biotechnology 2025 25:108
    Content type: Research Published on:

  20. The pathogenesis of thyroid carcinoma (TC) involves various factors, with the interplay between hormonal and environmental influences being particularly critical. The gut microbiome, a long-overlooked risk fac...

    Authors: Junyu Liu, Jiajun Huo, Zhi Zhang, Xiongsheng Xiao, Siyi Li, Yongkang Wu, Weijie Chen, Zhuoting Chen, Changwei Zheng, Muge Liu, Baibei Li, Guiping Zhou, Zhibin Huang, Jinquan Li, Bin Liu, Haiqing Luo…
    Citation: BMC Biotechnology 2025 25:107
    Content type: Research Published on:

  21. The World Health Organization (WHO) recommends combination therapy with two non-overlapping monoclonal antibodies (mAbs) to enhance protection in Rabies post-exposure prophylaxis (PEP). While bispecific antibo...

    Authors: Zhigao Zhang, Jia Li, Guanfeng Lin, Shouchun Cao and Yingsong Wu
    Citation: BMC Biotechnology 2025 25:106
    Content type: Research Published on:

  22. Echis ocellatus is a highly venomous snake that can cause serious medical complications due to the presence of toxic proteins in its venom. These proteins, such as echicetin and phospholipase A2 (PLA2), often cau...

    Authors: O. O. Oyedara, B. S. Ajisebiola, O. E. Abioye, O. A. Fadare, O. A. Olatunji, F. M. Adeyemi, M. N. Enahoro, S. F. Popoola, O. O. Oluyide and Z. A. Adeyemi
    Citation: BMC Biotechnology 2025 25:105
    Content type: Research Published on:

  23. In this work, a novel, eco-friendly composite material composed of MgAl-layered double hydroxide and cuttlebone (LDH/CB) was synthesized for the efficient adsorption of Congo Red dye from aqueous solutions. Th...

    Authors: Ramzi Chalghaf, Saber Boubakri, Zakarya Ahmed, Bilel Hadrich, Abdesslem Ben Haj Amara and Hafsia Ben Rhaiem
    Citation: BMC Biotechnology 2025 25:104
    Content type: Research Published on:

  24. Pancreatic cancer (PC) remains one of the deadliest cancer types, with limited success in treatment despite advances in research. MAP4K4 is overexpressed in pancreatic tumors and linked to disease progression,...

    Authors: Nigar Kantarci-Carsibasi, Münteha Girgin, Nursah D. Fidan, Tugba Bal and Shirin Tarbiat
    Citation: BMC Biotechnology 2025 25:103
    Content type: Research Published on:

  25. Urinary bladder cancer remains a significant global health challenge, with effective early preventive strategies urgently needed to reduce incidence and progression. This study explores the prophylactic potent...

    Authors: Silvia Botrous, Ayaat Elmaghraby, Samar El Achy, Yehia Mustafa and Salah Abdel-Rahman
    Citation: BMC Biotechnology 2025 25:102
    Content type: Research Published on:

  26. Ranitidine is widely used to treat gastrointestinal conditions, but recent studies have revealed severe potential side effects, including a link to cancer. Therefore, this study aims to develop a new gastro-re...

    Authors: Shimaa A. Sadek, Sohair R. Fahmy, Sara Bayoumi Ali, Marwa Ahmed Abdelfattah, Ahmed Mostafa Fahmy, Kirolos R. Mansour, Haneen Abdullah, Yousef Mohamed, Nada Hazem, Arsany Ehab Fayez, Christine Fouad Nasr, Gana Khaled Desouky, Abdelrahman W. Hassan and Khadiga M. Gaafar
    Citation: BMC Biotechnology 2025 25:101
    Content type: Research Published on:

  27. Patulin (PAT), a mycotoxin produced primarily by Penicillium expansum, poses significant health risks and frequently contaminates apples and apple-derived products, often exceeding permissible safety limits. This...

    Authors: Kopano Mapheto, Oluwakamisi Festus Akinmoladun, Tiisetso Colleen Maphaisa and Patrick Berka Njobeh
    Citation: BMC Biotechnology 2025 25:100
    Content type: Research Published on:

  28. This study investigates the effect of different liquefaction temperatures (50–70 °C) and four commercial enzyme formulations on glucose release and subsequent ethanol yield, using mixed waste baked products as...

    Authors: Mervat Almuhammad, Ralf Kölling and Daniel Einfalt
    Citation: BMC Biotechnology 2025 25:99
    Content type: Research Published on:

  29. The composition and roles of intestinal microbial populations have been clarified including mammals and humans however, less is understood concerning the gut microbiota of mollusks. For the first time, we inve...

    Authors: Reham Alaa Eldin Shaker, Rasha A. Hashem, Mariam Hassan, Amina M. Ibrahim, Yasser M. Ragab and Rania Abdelmonem Khattab
    Citation: BMC Biotechnology 2025 25:98
    Content type: Research Published on:

  30. In China, lung cancer stands as the leading cause of cancer-related deaths, often resulting in brain metastases (BM) that severely compromise patients’ quality of life and reduce survival outcomes. The deliver...

    Authors: Yuan Lu, Yan Qiao, Ting Wu, Yijing Zhang, JiaXin Shi and Jun Jiang
    Citation: BMC Biotechnology 2025 25:97
    Content type: Research Published on:

  31. Ultraviolet B (UVB) radiation severely damages human skin by causing DNA damage, oxidative stress, and collagen degradation. This study explored the photoprotective properties of Asparagus cochinchinensis extract...

    Authors: Xing Wang, Tianyu Lv, Chuang Zhang, Xixian Li, Jiayi Chen, Kailing Guo, Yichao Huang, Yiwei Zhao, Zhuo Wang and Zujun Deng
    Citation: BMC Biotechnology 2025 25:96
    Content type: Research Published on:

  33. Ti6Al4V (TC4) widely used in bone implants, has good mechanical properties but unremarkable bone-forming capacity. Tantalum (Ta) features excellent biocompatibility and suitability for osteogenesis, albeit wit...

    Authors: Jialiang Li, Yuxin Gong, Yuewen Xue, Zhengtuan Guo, Chong Xie, Fangfang Xu, Guangbin Zhao, Zhengjie Lin and Xijing He
    Citation: BMC Biotechnology 2025 25:94
    Content type: Research Published on:

  34. Cell-free protein synthesis (CFPS) is one approach to address the increasing demand for complex recombinant proteins in various applications, especially in the pharmaceutical sector. CFPS offers a variety of a...

    Authors: Paul-Joachim Niehoff, Sarah Luise Straaten, Anna Luca Ida Hampe, Yannick Flaskamp, Johannes Hemmerich, Hannes Juergens, Robin Roentgen, Ricarda Finnern and Jochen Büchs
    Citation: BMC Biotechnology 2025 25:93
    Content type: Research Published on:

  36. Colorectal cancer is one of the deadliest forms of gastrointestinal cancer, with conventional treatments often facing significant limitations. As a result, new approaches, particularly in targeted drug deliver...

    Authors: Razie Ezati, Behrooz Johari, Jaber Yousefi Seyf, Yousef Mortazavi, Mehdi Azizi and Hadi Samadian
    Citation: BMC Biotechnology 2025 25:91
    Content type: Research Published on:

  38. Natural killer (NK) cell immunotherapy is a promising approach for cancer treatment. However, its extensive clinical application was limited to the large-scale clinical-grade expansion of NK cells. In this stu...

    Authors: Sha Gong, Nan Mei, Jun Wang, Junsheng Zhu, Lu Wang, Xiaohong Lu, Pengcheng He, Weiwei Chen, Lei Xi, Yingying Bao, David N. Wald, Xiaohu Fan and Huaiyu Wang
    Citation: BMC Biotechnology 2025 25:89
    Content type: Research Published on:

  39. Spider silk is highly attractive material because of its superior mechanical properties and excellent biocompatibility, enabling it to self-assemble into a wide range of morphological structures for drug deliv...

    Authors: Ben Wang, Hongbo Li, Ying Chen, Zhi Chen, Pingping Li, Xi Zhang and Xiaoji Lin
    Citation: BMC Biotechnology 2025 25:88
    Content type: Research Published on:

  40. Accurately predicting the therapeutic response of non-small cell lung cancer (NSCLC) patients to tyrosine kinase inhibitors (TKIs) is of significant clinical importance. The use of TKIs in clinical is primaril...

    Authors: Ying Dong, Jinhang Li, Jia Wu, Lu Huang, Xiaoqiong Li, Qiaoxuan Zhang, Xianzhang Huang and Pengwei Zhang
    Citation: BMC Biotechnology 2025 25:87
    Content type: Research Published on:

  42. Alkaline proteases are hydrolytic enzymes that play a crucial role in various biological processes. Proteases produced by halophiles showed exceptional efficiency in breaking down the complex structures rangin...

    Authors: Mandragutti Teja, Tura Safawo Jarso, Dokka Muni Kumar and Sudhakar Godi
    Citation: BMC Biotechnology 2025 25:85
    Content type: Research Published on:

  45. Novel antifungal compounds effective against phytopathogenic fungiwere identified by evaluating an n-butanol extract obtained from the fermentation broth of Streptomyces diastatochromogenes strain No.1628. The ex...

    Authors: Ming-Yun Wang, Ke-Qi Ye, Dan-Ting Li, Chun-Li Guo, Jia-Cheng Ge, Xiao-Ping Yu and Xu-Ping Shentu
    Citation: BMC Biotechnology 2025 25:82
    Content type: Research Published on:

    The Correction to this article has been published in BMC Biotechnology 2025 25:86

  46. Tuberculosis (TB) and lung cancer (LC) are among the leading causes of death worldwide and present serious challenges in diagnosis and treatment. Therefore, developing new strategies for their treatment is cru...

    Authors: Mojgan Sheikhpour, Mobina Maleki, Hanie Sakhi, Abolfazl Movafagh, Seyed Ali Nojoumi and Leila Ghazizadeh
    Citation: BMC Biotechnology 2025 25:81
    Content type: Research Published on:

  47. The repair of bone defects remains a significant clinical challenge. Although magnesium (Mg)-based biomimetic scaffolds are widely utilized for bone defect repair, the release of Mg2+ ions often leads to an al...

    Authors: Shengyu Long, Wentong Wang, Yongcheng Chen, Zhihua Wang, Hao Duan, Ping Yuan, Yunrong Xu, Denghui Li, Wan Zhang, Weizhou Wang and Fei He
    Citation: BMC Biotechnology 2025 25:80
    Content type: Research Published on:

  48. Virus-like particles (VLPs) offer potentially high-immunogenicity/low-cost vaccine platforms. SARS-CoV-2 VLPs production is achieved via transient transfection of genes encoding viral structural proteins, but ...

    Authors: Yu Liu, Zhian Chen, Li Yang, Chunmei Gan, Jieshi Tang, Zhaoyue Zheng, JingYa Ye, C. Alexander Valencia, Hoi Yee Chow and Biao Dong
    Citation: BMC Biotechnology 2025 25:79
    Content type: Research Published on:

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