Sponsors
My research is currently sponsoreded by grants from
the National Science Foundation (NSF) and
the National Institutes of Health (NIH),
and include
- NSF-DDDAS-0540063
Dynamic Data-Driven
System for Laser Treatment of Cancer
An interdisciplinary collaboration with Prof. J.T.Oden
of The Institute for
Computational Engineering and Sciences Prof. J.C.Browne
of Computer Sciences
, Prof. K.R.Diller of Biomedical
Engineering , Dr.
J.Hazle, MD of The University
of Texas MD Anderson Cancer Center, to develop a dynamic data-driven
planning, control, and visualization system for laser treatment
of cancer. The proposed research is to develop a dynamic data-driven
planning, control, and visualization system for the laser treatment
of cancer. The proposed research includes development of a family
of mathematical and computational models of hio-heat transfer,
tissue damage, and tumor viability, dynamic calibration, verification
and validation processes based protocols using model predictions.
- NIH-R01
GM074258-02
Hierarchical
Methods for Large Biomolecular Complexes
To develop and implement efficient algorithms for determining
structural features of macromolecules from 3D-EM (Electron Microscopy)
maps at multiple resolutions, and for generating hierarchical,
volumetric spline approximations of the determined structural
features to facilitate fast Fourier based matching of geometry
and imaging.
- NIH-R01
GM073087-01
A
New Approach to Rapid Protein-Protein Docking
The principal aims are to develop, implement and test novel mathematical
algorithms that speed up computational protein-protein docking
especially for larger problems, as well as to significantly improve
the prediction of protein-protein binding. This collaborative
project also has a subcontract to Dr. Art Olson and Dr. Michel
Sanner at The Scripps Research Institute, San Diego, CA for testing
and validation.
- NIH-NIBIB-R01-EB4873
Software
Maintenance for Biomolecular Complexes
This project aims are in the development and maintenance of an
integrated Molecular Visualization and Processing environment
(MVP) consisting of volumetric image processing, geometry processing,
finite element meshing, analysis, and surface/volume rendering
libraries and software tools. In particular we continue the development
of a combination of image and geometry manipulations biomolecular
structures and properties manipulation algorithm and data structures
for increased functionality of the libraries and tools which form
our MVP. We are maintaining, developing and testing three principal
software tools: an interactive volumetric map exploration and
processing tool (VolRover) primarily for 3D reconstructed Electron
Microscopy (EM) maps, an interactive synthetic Texture Molecular
visualization and processing tool (TexMol) primarily for large
molecular and macromolecular structure models, and a Level Set
Boundary Interior Exterior boundary/finite element Meshing tool
(LBIE-Mesher) for macromolecular structures, and for aiding boundary
and finite element based biophysical simulations. Several of the
libraries (e.g. segmentation, contouring, volume-rendering), of
our MVP are also being disseminated through the public domain
and have already achieved widespread utilization by co-developers
of tools for computational structural biology, and computational
biophysics and biochemistry communities.
My research publications are available here, as is
my Curriculum Vitae.
