The "exposome"—the array of environmental exposures from diet to chemical to infection—is vast, dynamic, and intertwined with biology across scales, but unlike the genome remains elusive despite thousands of candidate studies.
The Zoonomia Project, one of the largest comparative genomics initiatives ever undertaken, compared 240 mammalian species spanning over 100 million years of evolutionary history.
Deep learning is fueling a revolution in genomics, enabling the development of a new generation of analysis tools that offer unprecedented accuracy.
Alzheimer’s disease (AD) remains one of the most pressing medical challenges, with limited therapeutic options and heterogeneous disease trajectories complicating diagnosis and treatment.
Imaging has been the primary means of diagnosing as well as tracking the progression of many diseases for decades but has largely been collected in isolation.
Human genomics has relied on a single reference genome for the last twenty years.
Biological replicators are locked in deeply intertwined genetic conflicts with each other.
All of life encodes information with DNA.
Recent years have seen dramatic advances in both experimental determination and computational prediction of macromolecular structures.
Deep generative models are increasingly powerful tools for the in silico design of novel proteins.