ELM - instance TRG_NES_CRM1_1 in sequence P04637 at position 339

ELM

The Eukaryotic Linear Motif resource for

Functional Sites in Proteins

o Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI000923	P04637 TP53 P53_HUMAN	339	352	ERFEMFRELNEALELKDAQA	TP	---	Homo sapiens (Human)	393

o Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0074	mutation analysis	in vivo/in vitro	O'Keefe,2003	support	certain	FeatureDetection
experimental	MI:0405	competition binding	in vitro	O'Keefe,2003	support	certain	InteractionDetection

o Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000518:
ELM Switch SWTI000518
Alternative splicing removes the nuclear export signal (NES) of Cellular tumor antigen p53 (TP53), abrogating binding to Exportin-1 (XPO1) and export from the nucleus.

o Pathways

KEGG: The sequence P04637 is implicated in the following 51 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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