Description:
Alternative splicing removes the nuclear export signal (NES) of Cellular tumor antigen p53 (TP53), abrogating binding to Exportin-1 (XPO1) and export from the nucleus.
Participants:
(1) Cellular tumor antigen p53 (TP53)
(2) Exportin-1 (XPO1)
(1) p53 isoforms can regulate p53 transcriptional activity.
Bourdon et al. Genes Dev. (2005)
(2) p53 isoforms - a conspiracy to kidnap p53 tumor suppressor activity?
Marcel et al. Cell. Mol. Life Sci. (2009)
Other switches involving participants
Cellular tumor antigen p53 (TP53) - 10 more (view)
Exportin-1 (XPO1) - 7 more (view)
Other switches involving interfaces
TRG_NES_CRM1_1 - 3 more (view)
Exportin 1-like protein - 9 more (view)
