ELM - instance DEG_SCF_COI1_1 in sequence Q9S7M2 at position 205

ELM

The Eukaryotic Linear Motif resource for

Functional Sites in Proteins

o Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002517	Q9S7M2 TIFY10B TI10B_ARATH	205	222	PIARRASLHRFLEKRKDRIT	TP	---	Arabidopsis thaliana (Thale cress)	249

o Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0018	two hybrid	in vivo	Melotto,2008	support	certain	InteractionDetection

o Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000721:
ELM Switch SWTI000721
Binding of Protein TIFY 10B (TIFY10B) to Coronatine-insensitive protein 1 (COI1), an F-box substrate recognition subunit of the SCF E3 ubiquitin ligase, depends on binding of the plant hormone jasmonate to COI1, as this pre-assembled complex provides a composite binding site for the degron motif in TIFY10B. Subsequent ubiquitylation of TIFY10B by the SCF targets this transcriptional repressor for proteasomal degradation, a pre-requisite for the transcriptional response to jasmonate.

o Pathways

KEGG: The sequence Q9S7M2 is implicated in the following 1 Pathway: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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