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Featured Citations

Delta-type glutamate receptors are ligand-gated ion channels. Wang H, Ahmed F et al. Nature. 2025 Nov 27;647(8091):1063–1071.

Structural basis of T-loop-independent recognition and activation of CDKs by the CDK-activating kinase. Cushing VI, McGeoch AJS et al. Science. 2025 Nov 27;390(6776):911-917.

Rapid compensatory evolution within a multiprotein complex preserves telomere integrity. Lin SY, Futeran HR et al. Science. 2025 Nov 27;390(6776):918-924.

Myeloperoxidase transforms chromatin into neutrophil extracellular traps. Burn GL, Raisch T et al. Nature. 2025 Nov 20;647(8090):747-756.

Sex and smoking bias in the selection of somatic mutations in human bladder. Calvet F, Blanco Martinez-Illescas R et al. Nature. 2025 Nov 13;647(8089):436-444.

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News

November 21, 2025

The ChimeraX 1.11 release candidate is available – please try it and report any issues. See the change log for what's new. This will be the last release to support Red Hat Enterprise Linux 8 and its derivatives.

July 24, 2025

ChimeraX 1.10.1 is now available, fixing the problem in 1.10 of repeat registration requests to some users.

June 26, 2025

The ChimeraX 1.10 production release is available! See the change log for what's new.

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UCSF ChimeraX

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.

ChimeraX is developed with support from National Institutes of Health R01-GM129325.

Bluesky logo ChimeraX on Bluesky: @chimerax.ucsf.edu

Feature Highlight

3eeb assembly 1 Coulombic ESP coloring

Coulombic Electrostatic Potential

Coulombic electrostatic potential (ESP) can be calculated and displayed with surface coloring using the command coulombic or the Molecule Display icon . No separate calculation or input ESP file is required. The image shows the first assembly defined for PDB 3eeb, the protease domain of a toxin from Vibrio cholerae, with the default Coulombic coloring: red-white-blue over the value range –10 to 10. For image setup other than orientation, see the command file coulombic.cxc.

For how to add a color key and associated label, see the Protein-Ligand Binding Sites tutorial.

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Example Image

HIV-1 protease B-factor coloring

B-factor Coloring

Atomic B-factor values are read from PDB and mmCIF input files and assigned as attributes that can be shown with coloring and used in atom specification. This example shows B-factor variation within a structure of the HIV-1 protease bound to an inhibitor (PDB 4hvp). For complete image setup, including positioning, color key, and label, see the command file bfactor.cxc.

Additional color key examples can be found in tutorials: Coloring by Electrostatic Potential, Coloring by Sequence Conservation

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