The Mayflower eventually set sail from Plymouth, UK, on 16 September 1620 to start what would prove to be a treacherous transatlantic voyage to America.
On board were more than 100 men, women and children – passengers and crew from different walks of life across England and the Dutch city of Leiden.
Four centuries years later, a number of special events were planned to mark the anniversary - including an online documentary presented by well-known TV historian Dan Snow which aired on 16 September here on the Mayflower 400 UK website.
The documentary reflected the story of the colonists, the impact their arrival had on the Native American people who helped them, and the wider colonial context of this journey.
It also included a look at some of the cultural projects involved in the commemorative year. The anniversary programme importantly involved representatives from the Wampanoag nation, who told their side of this story in their own words for the first time having been censored or not included in previous anniversaries.
Below you'll find details of news, events, videos and articles relating to the anniversary from across the destinations linked to the Mayflower story.