Subtype-resolved snRNA-seq analysis of TREM2–amyloid interactions in 5XFAD Alzheimer's mouse model. R/Seurat v5 pipeline: QC, Allen Brain Atlas label transfer (25 subtypes), pseudobulk DESeq2, cross-comparison gene classification (Cat1–6), multi-database ORA/GSEA, and partition analysis.

bioinformatics deseq2 single-cell alzheimers-disease gsea 5xfad seurat trem2 snrna-seq

• Updated May 7, 2026
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