Ziresovir

Medication

Pharmaceutical compound

Ziresovir
Clinical data

Trade names	Ziresovir
Legal status
Legal status	US:Investigational New Drug
Identifiers
IUPAC name N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxo-3,5-dihydro-2H-1λ6,4-benzothiazepin-4-yl)-6-methylquinazolin-4-amine
CAS Number	1422500-60-4
PubChem CID	71262247
ChemSpider	58810221
UNII	XCF42D7AG4
Chemical and physical data
Formula	C₂₂H₂₅N₅O₃S
Molar mass	439.53g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC1=CC2=C(C=C1)N=C(N=C2NCC3(COC3)N)N4CCS(=O)(=O)C5=CC=CC=C5C4
InChI InChI=1S/C22H25N5O3S/c1-15-6-7-18-17(10-15)20(24-12-22(23)13-30-14-22)26-21(25-18)27-8-9-31(28,29)19-5-3-2-4-16(19)11-27/h2-7,10H,8-9,11-14,23H2,1H3,(H,24,25,26) Key:GAAICKUTDBZCMT-UHFFFAOYSA-N

Ziresovir (RO-0529, AK0529) is an antiviral drug which was developed as a treatment for respiratory syncytial virus. It acts as a fusion inhibitor, and has shown good results in Phase II and III clinical trials.^[1]^[2]^[3]

References

NS3/4A protease inhibitors (–previr)	Asunaprevir Boceprevir ^‡ Ciluprevir ^§ Danoprevir ^† Faldaprevir ^‡ Glecaprevir Grazoprevir Narlaprevir Paritaprevir Simeprevir Sovaprevir ^† Telaprevir ^‡ Vaniprevir Vedroprevir ^§ Voxilaprevir
NS5A inhibitors (–asvir)	Coblopasvir Daclatasvir ^# Elbasvir Ledipasvir Netanasvir Odalasvir ^† Ombitasvir Pibrentasvir Ravidasvir ^† Ruzasvir ^† Samatasvir ^† Velpatasvir
NS5B RNA polymerase inhibitors (–buvir)	Beclabuvir ^† Bemnifosbuvir ^† Dasabuvir ^# Deleobuvir ^§ Encofosbuvir Filibuvir ^§ GS-6620 ^§ IDX-184 ^§ Setrobuvir ^§ Sofosbuvir ^# Tegobuvir ^§ TMC-647055 ^§ Radalbuvir ^† Uprifosbuvir ^†
Combination drugs	Elbasvir/grazoprevir Glecaprevir/pibrentasvir Ledipasvir/sofosbuvir ^# Ombitasvir/paritaprevir/ritonavir ^# Sofosbuvir/daclatasvir Sofosbuvir/velpatasvir ^# Sofosbuvir/velpatasvir/voxilaprevir

Anti-influenza agents

Multiple/general

Interferon	Interferon alfa 2b Peginterferon alfa-2a ^# Peginterferon alfa-2b ^#
3CL protease inhibitors (–trelvir)	Atilotrelvir Ensitrelvir ^† Ibuzatrelvir Leritrelvir Lufotrelvir Nirmatrelvir ^† (+ritonavir)^† Rupintrivir Simnotrelvir (+ritonavir ^†)
RNA pol inhibitors	CMX521 ^§ Deuremidevir ^† Favipiravir Galidesivir ^† GS-441524 ^§ Remdesivir MK-608 ^§ Mericitabine ^† Molnupiravir NITD008 ^§ Ribavirin ^# Taribavirin ^† Triazavirin Valopicitabine ^†
Multiple/Unknown/Other	EICAR ^§ Merimepodib ^§ Moroxydine Presatovir ^†

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