ZNF277

Protein-coding gene in the species Homo sapiens

ZNF277

Identifiers

ZNF277 , NRIF4, ZNF277P, zinc finger protein 277

External IDs

OMIM: 605465; MGI: 1890393; GeneCards: ZNF277

Gene location (Human)
Chromosome 7 (human)
Chr.	Chromosome 7 (human) ^[1]
Chromosome 7 (human) Genomic location for ZNF277 Genomic location for ZNF277
Band	7q31.1	Start	112,206,695 bp ^[1]
Band	7q31.1	End	112,343,934 bp ^[1]

Gene location (Mouse)
Chromosome 12 (mouse)
Chr.	Chromosome 12 (mouse)^[2]
Chromosome 12 (mouse) Genomic location for ZNF277 Genomic location for ZNF277
Band	12\|12 B1	Start	40,365,045 bp ^[2]
Band	12\|12 B1	End	40,495,901 bp ^[2]

RNA expression pattern

Bgee

Human	Mouse (ortholog)
Top expressed in Achilles tendon monocyte germinal epithelium islet of Langerhans body of pancreas ganglionic eminence jejunal mucosa oocyte skin of thigh gallbladder	Top expressed in primary oocyte cumulus cell efferent ductule vas deferens abdominal wall medial ganglionic eminence zygote secondary oocyte ovary endocardial cushion
More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	DNA binding metal ion binding nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component	nucleus
Biological process	regulation of cellular senescence regulation of transcription, DNA-templated transcription, DNA-templated cellular response to hydrogen peroxide regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO

Orthologs

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse

Entrez


11179


246196

Ensembl


ENSG00000198839


ENSMUSG00000055917

UniProt


Q9NRM2


E9Q6D6

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 7: 112.21 – 112.34 Mb

Chr 12: 40.37 – 40.5 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human View/Edit Mouse

Zinc finger protein 277 is a protein that in humans is encoded by the ZNF277 gene (previously ZNF277P).^[5]^[6]^[7]^[8] ZNF277 is predicted to be a transcription factor which is involved in regulating cellular senescence.^[9] The gene ZNF277 was truncated from its ancestral form, leading to it be labeled as a pseudogene in some places, but is now thought to produce a functionally modified protein.^[7]^[8]

References

[edit ]

1 2 3 GRCh38: Ensembl release 89: ENSG00000198839 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000055917 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Liang H, Guo W, Nagarajan L (Aug 2000). "Chromosomal mapping and genomic organization of an evolutionarily conserved zinc finger gene ZNF277". Genomics. 66 (2): 226–8. doi:10.1006/geno.2000.6198. PMID 10860669.
↑ Liang H, Castro PD, Ma J, Nagarajan L (Oct 2005). "Finer delineation and transcript map of the 7q31 locus deleted in myeloid neoplasms". Cancer Genet Cytogenet. 162 (2): 151–9. doi:10.1016/j.cancergencyto.2005年03月01日9. PMID 16213364.
1 2 Hahn Y, Lee B (Feb 2006). "Human-specific nonsense mutations identified by genome sequence comparisons". Hum Genet. 119 (1–2): 169–78. doi:10.1007/s00439-005-0125-6. PMID 16395595. S2CID 21059468.
1 2 "Entrez Gene: ZNF277P zinc finger protein 277 pseudogene".
↑ "Q9NRM2 · ZN277_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026年08月03日.