VUF-8430
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| Names | |
|---|---|
| Preferred IUPAC name
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| Identifiers | |
3D model (JSmol) |
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| Abbreviations | VUF-8430 |
| ChEMBL | |
| ChemSpider | |
PubChem CID |
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| UNII | |
CompTox Dashboard (EPA) |
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| Properties | |
| C4H11N5S | |
| Molar mass | 161.23g·mol−1 |
| log P | −1.367 |
Except where otherwise noted, data are given for materials in their standard state (at 25°C [77°F], 100kPa).
| |
Chemical compound
VUF-8430 is a histamine agonist [1] selective for the H4 subtype.[2]
References
[edit ]- ↑ Smith FM, Haskelberg H, Tracey DJ, Moalem-Taylor G (2007). "Role of histamine H3 and H4 receptors in mechanical hyperalgesia following peripheral nerve injury" . Neuroimmunomodulation. 14 (6): 317–25. doi:10.1159/000125048. PMID 18401194. S2CID 23020760.
- ↑ Lim, HD; Smits, RA; Bakker, RA; Van Dam, CM; De Esch, IJ; Leurs, R (2006). "Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H4 receptor agonist". Journal of Medicinal Chemistry. 49 (23): 6650–1. doi:10.1021/jm060880d. PMID 17154494.
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