Talk:Lingual lipase
It is of interest to the following WikiProjects:
What exactly is meant by: "In the uterus, the fetus is dependent on a high-carbohydrate diet" Fetuses do not eat. Fetuses are nourished via substrate exchange across the placenta. —Preceding unsigned comment added by 169.230.237.173 (talk) 01:12, 21 April 2011 (UTC) Reply
While trying to figure out what gene encodes for this enzyme, I kept being led back to rat studies. There are some claims of trace amounts of this occurring in humans like here[1] , but that is really old and based on cadavers, which doesn’t make me confident there wasn’t contamination.
Other studies say it (the rat version) is related to gastric lipase, so I thought maybe it could be encoded by the same gene in humans, but that gene doesn’t appear to have any expression outside the GI tract, though there could be problems with methodology Pabnau (talk) 17:17, 14 July 2026 (UTC) Reply
- Sure enough, it sounds like the existence and significance in humans is currently under debate:
- "A debate still exist about the existence of a lingual lipase in human [30, 86, 140], an enzyme that has been demonstrated to be present and active in rat and mice tongue only and which is the product of a gene ortholog [53] to the gene of gastric lipase [24] in humans and many other species."
- (https://link.springer.com/chapter/10.1007/978-3-030-56909-9_1)
- I’ll see if I can adjust the article to make this clearer. Pabnau (talk) 21:54, 14 July 2026 (UTC) Reply