Talk:Genetic disorder

Mendelian disorder redirects to this article, but it is barely mentioned. It would be good to either stop redirecting or explain properly. pgr94 (talk) 10:54, 1 June 2016 (UTC) Reply

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Hello, friends:

So I'm coming here from the genetics task force. While adding more references, do you think it would be a good idea to add onsets of different genetic diseases, or is that a matter for another article?

Thank you. Poeticfeelings (talk) 15:31, 1 July 2019 (UTC) Reply

This article was the subject of a Wiki Education Foundation-supported course assignment, between 22 August 2022 and 9 December 2022. Further details are available on the course page . Student editor(s): Sanjana muppavarapu (article contribs ).

— Assignment last updated by Prabal09 (talk) 17:24, 17 September 2022 (UTC) Reply

Where did the following quote come from?

Around 65% of people have some kind of health problem as a result of congenital genetic mutations.

The referenced article https://doi.org/10.4065%2F76.8.777 mentions the following prevalence:

The prevalence of genetic disease ranged from 4.5% to 12% of total admissions. A prevalence of 30% to 40% was documented by Hall et al and Scriver et al by using a broad definition of genetic conditions.

Uwsi (talk) 15:42, 27 November 2022 (UTC) Reply

I dug through the reference as well looking for the same information because that statistic sounds plainly ridiculous. Not to mention that the study population has an additional selection bias of "who went to the ED". Surely that sentence should be removed. Hexylena (talk) 11:33, 1 July 2025 (UTC) Reply

Oh yeah, this seems problematic. I’m going to remove it.

1) Kids ending up in the pediatric ER (mostly because they have a disease or other issue) is not a representative sample of the overall population.

2) For the 1/21 number, the 80% appears to be the fraction of rare diseases that have genetic causes, not the fraction of people with rare diseases whose disease is caused by a genetic disease, so you can’t multiply it by the prevalence of rare diseases. From the sources I tracked down (that show their work), ~80% of the disease prevalence from rare diseases is caused by the 4% (149) most common, rare diseases, so you have to be particularly careful when doing this kind of math. https://www.nature.com/articles/s41431-019-0508-0.pdf Pabnau (talk) 01:40, 15 December 2025 (UTC) Reply

I guess that calculation in (2) also falls under the Wikipedia:No original research, probably because of issues like this

"

Do not combine material from multiple sources to state or imply a conclusion not explicitly stated by any of the sources. Similarly, do not combine different parts of one source to state or imply a conclusion not explicitly stated by the source. If one reliable source says A and another reliable source says B, do not join A and B together to imply a conclusion C not mentioned by either of the sources. This would be improper editorial synthesis of published material to imply a new conclusion, which is original research.

" Pabnau (talk) 01:52, 15 December 2025 (UTC) Reply