Talk:Cortisone

Made by Calvin Donnell —Preceding unsigned comment added by 75.55.38.127 (talk) 21:47, 16 September 2008 (UTC) As far as I can judge, this article describes the hormone cortisol not cortisone. Cortisone, in my vocabulary, is a medical substance acting like cortisol. I am however not bold enough to go ahead mess around with this in English, not being a native English speaker - but if no objections arrive I will adjust this article according to my view on the subject. // Habj 19:59, 21 January 2006 (UTC) Reply

AFAIK, cortisone is synthetic cortisol. Also, Corticosterone is refered to here as unimportant. Yes, in human health as humans do not express it: It is the rodent version of cortisol. The claim that cortisol/cortisone is responsible for stress/ill-health correlation is oversimplistic. 1. In chronic stress cort. becomes downregulated and AVP becomes the major driver of the HPA axis, and hence the major driver of immune inhibition; 2. The autonomic nervous system also plays a major role in damping down immune responses during stress; 3. Autoimmune diseases actually benefit from high cortisol levels. There are many other substances that mediate immune supression eg substance P, NF kappa beta etc. It seems to be a problem here that the chemistry project run pages on biological molecules are over-simplistic wrt to the biology. Is there no biochemistry/cellular biology project similar to the chemistry one? I support the above edit.Povmcdov 15:47, 25 February 2007 (UTC) Reply

116.199.208.54 (talk) 19:48, 5 October 2008 (UTC)Cortisol? = cortisone??, also known as the stress hormone (steriod hormone). and clinical depression is influenced by the high levels of cortisol in the body/brian. Effects memory. peoples ability to encode memory drop when levels of cortisol is elevated. exercise can lower levels of cortisol116.199.208.54 (talk)Reply

—The preceding unsigned comment was added by Leonard G. (talk • contribs) 06:45, 19 December 2006 (UTC).Reply

Be careful! There is a mistake in the article: this is not a steroid-like structure on the picture! Look on the right for the structure:

Both the image in the article and the image on this page represent the same chemical compound - and they both have steroid structure. I don't see a mistake in either. The one in the article, however, is preferred because it contains additional stereochemical information that is not present in this one. --Ed (Edgar181) 14:52, 30 April 2007 (UTC) Reply

Effects and Uses section is weak. What are the uses? It seems there are some paragraphs missing. The 3rd paragraph begins: "One of cortisone's effects on..." -- it seems the writer assumes we already know what cortisone is used for, when he starts talking about side-effects. But his previous 2 paragraphs have nothing to that effect.

All that he says (in the preceding para) is: "...sometimes used as a drug to treat a variety of ailments..." -- duh? Of course it is; but .. what ailments? And how? Details, details.

Very surprising that this is omitted; the largest part of any Wiki article about any drug should be what it is used for. I understand that cortisone is used for arthritis; can this be confirmed? There should be an entire section devoted to this, if so.

Lots of work needed to clean this article up, I'm afraid. —Preceding unsigned comment added by Atikokan (talk • contribs) 01:04, 9 March 2008 (UTC) Reply

I am interested in potential side effects. Some years ago my doctor injected both my shoulders and elbows with cortisone because I had severe inflamation in the joints. Within weeks I gained about 60 pounds in weight and despite dieting I am unable to lose the extra weight. Yet doctors insist that my weight gain is not related to the injections. The Geologist (talk) 13:22, 11 March 2008 (UTC) Reply

I am also interested in more detail on how cortisone is used and how it works. I'm most familiar with it in the context of getting a cortisone shot for muscular and joint problems; would like to know what it does to help these problems, as suppressing the immune system doesn't seem directly applicable! Lyn (talk) 16:30, 20 October 2009 (UTC) Reply

Should Lewis Hastings Sarett be mentioned? He was th chemist at Merck doing the synthesis?--Stone (talk) 14:38, 24 May 2008 (UTC) Reply

The phrase "Because of cortisone's effect on the immune system, dogs treated with even moderate doses show an increase in thirst and urination frequency", doesn't make any sense. Cortisone does have an effect on the immune system, but this has no direct effect on the kidneys. It has some direct on the kidneys, and possibly, direct effects on thirst centres - hence the effects on urination and thirst —Preceding unsigned comment added by Excelis4 (talk • contribs) 08:58, 18 February 2010 (UTC) Reply

I agree. The reference is also probably incorrectly formatted, as it should refer to the actual paper in the Bonagura volume, where Bonagura is the editor. John Duncan (talk) 14:18, 17 July 2010 (UTC) Reply

Agreed. This statement as presented is generally misleading and essentially incorrect (any effect on fluid balance is likely due to a minimal mineralcorticoid effect, which in some instances are suppressed by exogenous glucocorticoid), further this statement is unsourced. I will remove it. --140.198.200.21 (talk) 16:10, 11 July 2011 (UTC) Reply

It reads really odd.94.234.170.2 (talk) 13:28, 6 September 2011 (UTC) Reply

Unknown at the time of the 1960 Presidential election, President John F. Kennedy took Cortisone supplements to counter the adrenal deficiency symptoms of Addison's Disease, which he denied having.[1] [2] 

This reference amounts to a bit of trivia added to the end of the history of the drug. If there is some reason why it belongs (Kennedy were to have been taking it as a test subject, etc., part of early research in the 1950s and so on, and the editor can establish this, and so on, then there is a place for it. Otherwise, it does not belong here in the main history section and in the absence of another section to which to relocate it, I am removing it. I am leaving it here in case someone wants to add a paragraph where this would be appropriate (list of famous people who have taken cortisone, or something like that). — Preceding unsigned comment added by 132.174.192.68 (talk) 17:00, 30 January 2013 (UTC) Reply

I observe that the IUPAC name for Prednisone differs very substantially from Cortisone even though the only difference is a diene -> ene. IANAOC, and I know small changes in structure CAN lead to vastly different namings, but in this case, since the "front to back" nature of the molecule doesn't change, I am surprised by the profound difference. Can someone check this? — Preceding unsigned comment added by 71.109.148.145 (talk) 10:49, 2 February 2016 (UTC) Reply

One of the first sentences in this article is "Cortisone is a synthetic corticosteroid, which is not released by the adrenal gland."

This is contradicted by the wikipedia page on the adrenal gland. In fact, the wikipedia page on the adrenal gland includes a graphic detailing which section of the adrenal gland cortisone is produced in.

I suspect but am not 100% sure that the wikipedia page on the adrenal gland is correct. I believe this article may need to be changed. Thoughts?

Chompy2357 (talk) 17:27, 17 February 2021 (UTC) Reply

This definitely needs to be changed. Cortisone and cortisol are both natural and can be converted into each other through the HSD11B1 and HSD11B2 enzymes. Cortisone is just an inactive metabolite of cortisol

Gould80 (talk) 11:00, 26 February 2021 (UTC) Reply  

About:

 Cortisone was first identified by the American chemists Edward Calvin Kendall
 and Harold L. Mason while researching at the Mayo Clinic.[9][10][11] 

A year would be very helpful here. (The year 1949 at the beginning of the next paragraph tells us nothing about the year of discovery. Sometimes researchers continue their research of the same field of study for many years or even decades.) Toddcs (talk) 04:00, 22 September 2021 (UTC) Reply

Those who already understand the terminology probably already know the material here. 168.103.36.155 (talk) 21:25, 24 March 2022 (UTC) Reply

@AlyInWikiWonderland:

Hi Aly. Let’s move the discussion here so this doesn’t turn into an edit war. Thank you for taking the time to put in citations. However, citations need to support the claims. As far as I can tell, "Pharmacokinetics and Pharmacodynamics of Systemically Administered Glucocorticoids" does not say that Cortisone is a glucocorticoid or mineralocorticoid agonist. On the contrary, while it is mentioned 4 times in the text, it is just repeatedly referred to as "inactive."

(And I’m running into similar problems while trying to verify other citations)

In particular, my understanding of the word "agonist" is that it directly binds to the corresponding receptor. For example: "Agonist: A ligand that binds to a receptor and alters the receptor state resulting in a biological response." (https://www.bumc.bu.edu/ppb/pharmacology-glossary/)

As far as I know it isn’t typically used to refer to chemicals that can get converted into agonists in the body, since that would make it hard to use the word precisely. It’s possible there are contexts where it is used in that sense, but in the case it would still tend to lead to confusion, so I feel we should avoid using it. Instead, in my opinion we should use more specific, unambiguous language

Edit*: Just to be clear why this is important. In pharmacology, cortisone may be thought of as pro-cortisol, but in anatomy/genetics it’s very different. The whole function of cortisone in the body is to *not* be an agonist, or at least be a much weaker agonist than cortisol. So putting an unqualified statement that cortisone is a glucocorticoid/mineralocorticoid receptor agonist is going to confuse the reader. Pabnau (talk) 18:48, 22 May 2026 (UTC) Reply

You are being overly pedantic and it's annoying. I have revised the text again. I hope that there will be no further complaints now. – AlyInWikiWonderland (talk, contribs) 19:18, 22 May 2026 (UTC) Reply

Sorry about that. It may seem pedantic if you’re coming from a pharmacology background, but I feel it’s very important from an anatomical function standpoint.

Anyways, thank you for making the changes. I think it is no longer likely to lead to misunderstandings, so I have no other complaints Pabnau (talk) 19:29, 22 May 2026 (UTC) Reply

It makes sense. All good. Sorry for getting annoyed. This article should probably be split into hormone/endogenous compound and medication articles like others (e.g. cortisol and hydrocortisone) and both expanded at some point. Then the different perspectives wouldn't be conflicting and jumbled up. – AlyInWikiWonderland (talk, contribs) 19:53, 22 May 2026 (UTC) Reply

No worries! I think splitting it would be reasonable if you think it has enough significance as a medication. That’s not something I know too much about Pabnau (talk) 20:01, 22 May 2026 (UTC) Reply