STK17A

Protein-coding gene in the species Homo sapiens

STK17A

Identifiers

STK17A , DRAK1, serine/threonine kinase 17a

External IDs

OMIM: 604726; HomoloGene: 55846; GeneCards: STK17A; OMA:STK17A - orthologs

Gene location (Human)
Chromosome 7 (human)
Chr.	Chromosome 7 (human) ^[1]
Chromosome 7 (human) Genomic location for STK17A Genomic location for STK17A
Band	7p13	Start	43,582,758 bp ^[1]
Band	7p13	End	43,650,713 bp ^[1]

RNA expression pattern

Bgee

Human	Mouse (ortholog)
Top expressed in lymph node epithelium of nasopharynx granulocyte appendix blood bone marrow ganglionic eminence ventricular zone vena cava Achilles tendon	n/a
More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	kinase activity transferase activity nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding
Cellular component	nucleus plasma membrane nuclear speck
Biological process	positive regulation of apoptotic process positive regulation of fibroblast apoptotic process protein phosphorylation intracellular signal transduction regulation of reactive oxygen species metabolic process phosphorylation apoptotic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9263


n/a

Ensembl


ENSG00000164543


n/a

UniProt


Q9UEE5


n/a

RefSeq (mRNA)

NM_004760

n/a

RefSeq (protein)

NP_004751

n/a

Location (UCSC)

Chr 7: 43.58 – 43.65 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Serine/threonine kinase 17a is a protein that in humans is encoded by the STK17A gene.^[3]

Function

[edit ]

This gene is a member of the death-associated protein (DAP) kinase-related apoptosis-inducing protein kinase family and encodes an autophosphorylated nuclear protein with a protein kinase domain. The protein has apoptosis-inducing activity.^[3]

In a recent study the gene (among others) shows a major role in centenarians longer lifespan.^[4]

References

[edit ]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164543 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: Serine/threonine kinase 17a".
^ Garagnani P, Marquis J, Delledonne M, Pirazzini C, Marasco E, Kwiatkowska KM, et al. (May 2021). Tyler JK, Suh Y, Shuldiner AR (eds.). "Whole-genome sequencing analysis of semi-supercentenarians". eLife. 10: e57849. doi:10.7554/eLife.57849 . PMC 8096429 . PMID 33941312.

Landa I, Ruiz-Llorente S, Montero-Conde C, Inglada-Pérez L, Schiavi F, Leskelä S, et al. (September 2009). "The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors". PLOS Genetics. 5 (9): e1000637. doi:10.1371/journal.pgen.1000637 . PMC 2727793 . PMID 19730683.
Sanjo H, Kawai T, Akira S (October 1998). "DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis". The Journal of Biological Chemistry. 273 (44): 29066–71. doi:10.1074/jbc.273.44.29066 . PMID 9786912.
Mao P, Hever MP, Niemaszyk LM, Haghkerdar JM, Yanco EG, Desai D, et al. (June 2011). "Serine/threonine kinase 17A is a novel p53 target gene and modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells". The Journal of Biological Chemistry. 286 (22): 19381–91. doi:10.1074/jbc.M111.218040 . PMC 3103316 . PMID 21489989.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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Function

References

Further reading