RRP8
From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
| RRP8 | ||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | ||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | RRP8 , KIAA0409, NML, ribosomal RNA processing 8, methyltransferase, homolog (yeast), ribosomal RNA processing 8 | |||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 615818; MGI: 1914251; GeneCards: RRP8 | |||||||||||||||||||||||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||
| Wikidata | ||||||||||||||||||||||||||||||||||||||||||||||||||
Ribosomal RNA-processing protein 8 is a protein that in humans is encoded by the RRP8 gene.[5] [6] The RRP8 protein is involved in regulating and silencing ribosomal DNA as part of the energy-dependent nucleolar silencing complex (eNoSC).[7] In particular, a component of the eNoSC complex, SIRT1, detects glucose starvation via NAD+/NADP+ levels, leading to the deacetylation of histone H3.[7] This triggers another subunit, SUV39H1, to perform dimethylation of H3 at 'Lys-9' (denoted H3K9me2), leading to a silent DNA state.[7] As part of this complex, the RRP8 protein binds to H3K9me2, and may act as methyltransferase, but its substrate(s) are currently unknown.[7]
References
[edit ]- 1 2 3 GRCh38: Ensembl release 89: ENSG00000132275 – Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030888 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307 . PMID 9455477.
- ↑ "Entrez Gene: KIAA0409 KIAA0409".
- 1 2 3 4 "O43159 · RRP8_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026年08月03日.
Further reading
[edit ]- Olsen JV, Blagoev B, Gnad F, etal. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006年09月02日6 . PMID 17081983. S2CID 7827573.
- Beausoleil SA, Villén J, Gerber SA, etal. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
- Nousiainen M, Silljé HH, Sauer G, etal. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103 . PMC 1459365 . PMID 16565220.
- Gerhard DS, Wagner L, Feingold EA, etal. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
- Strausberg RL, Feingold EA, Grouse LH, etal. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
- Scherl A, Couté Y, Déon C, etal. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617 . PMID 12429849.
- Andersen JS, Lyon CE, Fox AH, etal. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9 . PMID 11790298. S2CID 14132033.
External links
[edit ]- PDBe-KB provides an overview of all the structure information available in the PDB for Human Ribosomal RNA-processing protein 8 (KIAA0409)
Stub icon
This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by adding missing information.
Retrieved from "https://en.wikipedia.org/w/index.php?title=RRP8&oldid=1368687243"