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Propiverine

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Chemical compound
Pharmaceutical compound
Propiverine
Clinical data
AHFS/Drugs.com International Drug Names
ATC code
Legal status
Legal status
Pharmacokinetic data
Elimination half-life 20.1 h
Identifiers
  • 1-methylpiperidin-4-yl diphenyl(propoxy)acetate
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
Formula C23H29NO3
Molar mass 367.489 g·mol−1
3D model (JSmol)
  • CCCOC(C1=CC=CC=C1)(C2=CC=CC=C2)C(=O)OC3CCN(CC3)C
  • InChI=1S/C23H29NO3/c1-3-18-26-23(19-10-6-4-7-11-19,20-12-8-5-9-13-20)22(25)27-21-14-16-24(2)17-15-21/h4-13,21H,3,14-18H2,1-2H3 ☒N
  • Key:QPCVHQBVMYCJOM-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)   (verify)

Propiverine is an anticholinergic drug used for the treatment of urinary urgency, frequency and urge incontinence, all symptoms of overactive bladder syndrome.[2] [3] It is a muscarinic antagonist.[4]

References

[edit ]
  1. ^ "Digestive and bladder health". Health Canada . 9 May 2018. Retrieved 13 April 2024.
  2. ^ McKeage K (January 2013). "Propiverine: a review of its use in the treatment of adults and children with overactive bladder associated with idiopathic or neurogenic detrusor overactivity, and in men with lower urinary tract symptoms". Clinical Drug Investigation. 33 (1): 71–91. doi:10.1007/s40261-012-0046-9. PMID 23288694. S2CID 3399082.
  3. ^ Huang W, Zong H, Zhou X, Wang T, Zhang Y (December 2015). "Efficacy and Safety of Propiverine Hydrochloride for Overactive Bladder in Adult: a Systematic Review and Meta-analysis". The Indian Journal of Surgery. 77 (Suppl 3): 1369–1377. doi:10.1007/s12262-015-1264-1. PMC 4775592 . PMID 27011567.
  4. ^ BNF 61. London: British Medical Journal Group and Pharmaceutical Press. March 2011. p. 511. ISBN 978-0-85369-962-0.
mAChRs Tooltip Muscarinic acetylcholine receptors
Agonists
Antagonists
Precursors
(and prodrugs)


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