Picotamide
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Chemical compound
Pharmaceutical compound
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| ECHA InfoCard | 100.046.572 Edit this at Wikidata |
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| Formula | C21H20N4O3 |
| Molar mass | 376.416 g·mol−1 |
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Picotamide is a platelet aggregation inhibitor. It works as a thromboxane synthase inhibitor and a thromboxane receptor inhibitor, the latter by modifying cellular responses to activation of the thromboxane receptor.[1] Picotamide is licensed in Italy for the treatment of clinical arterial thrombosis and peripheral artery disease.[2]
References
[edit ]- ^ Ratti S, Quarato P, Casagrande C, Fumagalli R, Corsini A (August 1998). "Picotamide, an antithromboxane agent, inhibits the migration and proliferation of arterial myocytes". European Journal of Pharmacology. 355 (1): 77–83. doi:10.1016/S0014-2999(98)00467-1. PMID 9754941.
- ^ Capra V, Bäck M, Angiolillo DJ, Cattaneo M, Sakariassen KS (February 2014). "Impact of vascular thromboxane prostanoid receptor activation on hemostasis, thrombosis, oxidative stress, and inflammation". Journal of Thrombosis and Haemostasis. 12 (2): 126–137. doi:10.1111/jth.12472 . PMID 24298905.
Further reading
[edit ]- Celestini A, Violi F (2007). "A review of picotamide in the reduction of cardiovascular events in diabetic patients". Vascular Health and Risk Management. 3 (1): 93–8. PMC 1994050 . PMID 17583179.
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