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PRPF4B

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
PRPF4B
Available structures
PDB Ortholog search: PDBe RCSB
List of PDB id codes

4IAN, 4IFC, 4IIR, 4IJP

Identifiers
Aliases PRPF4B , PR4H, PRP4, PRP4H, PRP4K, dJ1013A10.1, pre-mRNA processing factor 4B
External IDsOMIM: 602338; MGI: 109584; HomoloGene: 134085; GeneCards: PRPF4B; OMA:PRPF4B - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr. Chromosome 6 (human) [1]
Band 6p25.2Start4,021,267 bp [1]
End4,064,983 bp [1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr. Chromosome 13 (mouse)[2]
Band 13|13 A3.3Start34,875,302 bp [2]
End34,906,064 bp [2]
RNA expression pattern
Bgee
Human Mouse (ortholog)
  • endothelial cell

  • Epithelium of choroid plexus

  • mucosa of paranasal sinus

  • Achilles tendon

  • epithelium of nasopharynx

  • ventricular zone

  • left ovary

  • body of uterus

  • right ovary

  • right uterine tube
  • fossa

  • condyle

  • genital tubercle

  • Paneth cell

  • tail of embryo

  • lobe of cerebellum

  • cerebellar vermis

  • substantia nigra

  • otic placode

  • saccule
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8899

19134

Ensembl

ENSG00000112739

ENSMUSG00000021413

UniProt

Q13523

Q61136

RefSeq (mRNA)

NM_003913
NM_176800

NM_013830

RefSeq (protein)

NP_003904

NP_038858

Location (UCSC)Chr 6: 4.02 – 4.06 Mb Chr 13: 34.88 – 34.91 Mb
PubMed search[3] [4]
Wikidata

Serine/threonine-protein kinase PRP4 homolog is an enzyme that in humans is encoded by the PRPF4B gene.[5] [6] [7]

Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs).[7]

Interactions

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PRPF4B has been shown to interact with Pinin.[8]

References

[edit ]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112739Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021413Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Aug 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31 . PMID 9628581.
  6. ^ Kojima T, Zama T, Wada K, Onogi H, Hagiwara M (Aug 2001). "Cloning of human PRP4 reveals interaction with Clk1". J Biol Chem. 276 (34): 32247–56. doi:10.1074/jbc.M103790200 . PMID 11418604.
  7. ^ a b "Entrez Gene: PRPF4B PRP4 pre-mRNA processing factor 4 homolog B (yeast)".
  8. ^ Dellaire, Graham; Makarov Evgeny M; Cowger Jeff J M; Longman Dasa; Sutherland Heidi G E; Lührmann Reinhard; Torchia Joseph; Bickmore Wendy A (Jul 2002). "Mammalian PRP4 Kinase Copurifies and Interacts with Components of Both the U5 snRNP and the N-CoR Deacetylase Complexes". Mol. Cell. Biol. 22 (14). United States: 5141–56. doi:10.1128/MCB.22.14.5141-5156.2002. hdl:11858/00-001M-0000-0029-BC76-A. ISSN 0270-7306. PMC 139773 . PMID 12077342.

Further reading

[edit ]
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