Oxolamine

Cough suppressant

Pharmaceutical compound

Oxolamine
Clinical data

AHFS/Drugs.com	International Drug Names
ATC code	R05DB07 (WHO )
Identifiers
IUPAC name N,N-diethyl-2-(3-phenyl-1,2,4-oxadiazol-5-yl)ethanamine
CAS Number	959-14-8 ^checkY
PubChem CID	13738
DrugBank	DB13216 ^checkY
ChemSpider	13143 ^checkY
UNII	90BEA145GY
KEGG	D07387 ^checkY
ChEMBL	ChEMBL1620875 ^☒N
CompTox Dashboard (EPA)	DTXSID5023403 Edit this at Wikidata
ECHA InfoCard	100.012.267 Edit this at Wikidata
Chemical and physical data
Formula	C₁₄H₁₉N₃O
Molar mass	245.326 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES n1c(onc1c2ccccc2)CCN(CC)CC
InChI InChI=1S/C14H19N3O/c1-3-17(4-2)11-10-13-15-14(16-18-13)12-8-6-5-7-9-12/h5-9H,3-4,10-11H2,1-2H3^checkY Key:IDCHQQSVJAAUQQ-UHFFFAOYSA-N^checkY
^☒NcheckY (what is this?) (verify)

Oxolamine is a cough suppressant ^[1] that is available as a generic drug in many jurisdictions.^[2]

Oxolamine also has anti-inflammatory activity, which causes a reduction in irritation of the nerve receptors of the respiratory tract.^[3]

It is mainly used for the treatment of pharyngitis, tracheitis, bronchitis, bronchiectasis and pertussis.^[3]

Oxolamine is not approved in the USA, it may be marketed elsewhere internationally as a cough suppressant. It is listed as a prescription drug in New Zealand legislation. Oxolamine is also approved in Taiwan for the treatment of respiratory tract inflammation.^[4]

References

[edit ]

^ de Groot AC (2022). "3.357 Oxolamine". Systemic Drugs. Monographs in Contact Allergy. Vol. 4 (First ed.). CRC Press. p. 712. ISBN 978-1-00-054991-1.
^ "Oxolamine". drugs.com. 19 April 2015. Archived from the original on 20 September 2018. Retrieved 23 January 2018.
^ ^a ^b "NCATS Inxight Drugs — OXOLAMINE CITRATE". drugs.ncats.io. Archived from the original on 2022年09月26日. Retrieved 2022年09月26日.
^ "Oxolamine". go.drugbank.com. Archived from the original on 2022年09月26日. Retrieved 2022年09月26日.