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Norquetiapine

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Pharmaceutical compound
Norquetiapine
Skeletal formula of norquetiapine
Clinical data
Other namesN-Desalkylquetiapine; NQTP
Drug class Atypical antipsychotic
ATC code
Identifiers
  • 6-piperazin-1-ylbenzo[b][1,4]benzothiazepine
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.118.138 Edit this at Wikidata
Chemical and physical data
Formula C17H17N3S
Molar mass 295.40g·mol−1
3D model (JSmol)
Boiling point 465.2°C (869.4°F) ±55.0 °C at 760 mmHg
  • C1CN(CCN1)C2=NC3=CC=CC=C3SC4=CC=CC=C42
  • InChI=1S/C17H17N3S/c1-3-7-15-13(5-1)17(20-11-9-18-10-12-20)19-14-6-2-4-8-16(14)21-15/h1-8,18H,9-12H2
  • Key:JLOAJISUHPIQOX-UHFFFAOYSA-N
(verify)

Norquetiapine, also known as N-desalkylquetiapine, is a 5-HT2B serotonin receptor modulator,[1] and norepinephrine reuptake inhibitor.[2] [3] It is the principal metabolite of quetiapine.[4] [5] [6]

References

[edit ]
  1. ↑ "CAS Common Chemistry". commonchemistry.cas.org. Archived from the original on 2025年08月12日. Retrieved 2026年07月07日.
  2. ↑ Jensen NH, Rodriguiz RM, Caron MG, Wetsel WC, Rothman RB, Roth BL (September 2008). "N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1A agonist, as a putative mediator of quetiapine's antidepressant activity". Neuropsychopharmacology . 33 (10): 2303–2312. doi:10.1038/SJ.NPP.1301646. PMID 18059438.
  3. ↑ Di Benedetto B, Kühn R, Nothdurfter C, Rein T, Wurst W, Rupprecht R (January 2012). "N-desalkylquetiapine activates ERK1/2 to induce GDNF release in C6 glioma cells: a putative cellular mechanism for quetiapine as antidepressant". Neuropharmacology . 62 (1): 209–216. doi:10.1016/j.neuropharm.201107001. PMID 21767553.
  4. ↑ Brunton L, Chabner B, Knollman B (2010). Goodman and Gilman's The Pharmacological Basis of Therapeutics (12th ed.). McGraw Hill Professional. ISBN 978-0-07-162442-8.
  5. ↑ PubChem. "Quetiapine". Pubchem.ncbi.NLM.nih.gov . Retrieved 2026年07月07日.
  6. ↑ "Norquetiapine". ChemSpider.com . Retrieved 2026年07月07日.
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