Myod family inhibitor domain containing

Protein-coding gene in the species Homo sapiens

MDFIC

Identifiers

MDFIC , HIC, MyoD family inhibitor domain containing, MDFIC1

External IDs

OMIM: 614511; MGI: 104611; HomoloGene: 18404; GeneCards: MDFIC; OMA:MDFIC - orthologs

Gene location (Human)
Chromosome 7 (human)
Chr.	Chromosome 7 (human) ^[1]
Chromosome 7 (human) Genomic location for MDFIC Genomic location for MDFIC
Band	7q31.1-q31.2	Start	114,922,094 bp ^[1]
Band	7q31.1-q31.2	End	115,019,917 bp ^[1]

Gene location (Mouse)
Chromosome 6 (mouse)
Chr.	Chromosome 6 (mouse)^[2]
Chromosome 6 (mouse) Genomic location for MDFIC Genomic location for MDFIC
Band	6\|6 A1	Start	15,720,660 bp ^[2]
Band	6\|6 A1	End	15,802,168 bp ^[2]

RNA expression pattern

Bgee

Human	Mouse (ortholog)
Top expressed in amniotic fluid tibia Epithelium of choroid plexus lactiferous duct skin of hip visceral pleura germinal epithelium mucosa of paranasal sinus periodontal fiber oral cavity	Top expressed in Epithelium of choroid plexus cumulus cell epithelium of lens ciliary body stroma of bone marrow iris right lung lobe choroid plexus of fourth ventricle conjunctival fornix calvaria
More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	transcription factor binding Tat protein binding protein binding cyclin binding
Cellular component	nucleolus nucleus cytoplasm Golgi apparatus nucleoplasm
Biological process	positive regulation of transcription, DNA-templated positive regulation of viral transcription regulation of Wnt signaling pathway viral process regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of protein import into nucleus negative regulation of transcription, DNA-templated
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


29969


16543

Ensembl


ENSG00000135272


ENSMUSG00000041390

UniProt


Q9P1T7


Q8BX65

RefSeq (mRNA)

NM_199072
NM_001166345
NM_001166346

NM_175088

RefSeq (protein)

NP_001159817
NP_001159818
NP_951038

NP_780297

Location (UCSC)

Chr 7: 114.92 – 115.02 Mb

Chr 6: 15.72 – 15.8 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human View/Edit Mouse

MyoD family inhibitor domain containing is a protein that in humans is encoded by the MDFIC gene. ^[5]

Function

[edit ]

This gene product is a member of a family of proteins characterized by a specific cysteine-rich C-terminal domain, which is involved in transcriptional regulation of viral genome expression. Alternative translation initiation from an upstream non-AUG (GUG), and an in-frame, downstream AUG codon, results in the production of two isoforms, p40 and p32, respectively, which have different subcellular localization; p32 is mainly found in the cytoplasm, whereas p40 is targeted to the nucleolus. Both isoforms have transcriptional regulatory activity that is attributable to the cysteine-rich C-terminal domain. Alternative splicing results in multiple transcript variants.

References

[edit ]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135272 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041390 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: MyoD family inhibitor domain containing" . Retrieved 2016年02月09日.

Function

References

Further reading