Mozavaptan

Chemical compound

Pharmaceutical compound

Mozavaptan
Clinical data

Routes of administration	Oral
ATC code	none
Legal status
Legal status	In general: ℞ (Prescription only)
Identifiers
IUPAC name N-[4-(5-Dimethylamino-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)phenyl]-2-methylbenzamide
CAS Number	137975-06-5 ^checkY
PubChem CID	119369
IUPHAR/BPS	2197
ChemSpider	106618 ^checkY
UNII	17OJ42922Y
ChEMBL	ChEMBL420762 ^checkY
CompTox Dashboard (EPA)	DTXSID8057641 Edit this at Wikidata
Chemical and physical data
Formula	C₂₇H₂₉N₃O₂
Molar mass	427.548 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES Cc1ccccc1C(=O)Nc2ccc(cc2)C(=O)N3c4ccccc4C(CCC3)N(C)C
InChI InChI=1S/C27H29N3O2/c1-19-9-4-5-10-22(19)26(31)28-21-16-14-20(15-17-21)27(32)30-18-8-13-24(29(2)3)23-11-6-7-12-25(23)30/h4-7,9-12,14-17,24H,8,13,18H2,1-3H3,(H,28,31)^checkY Key:WRNXUQJJCIZICJ-UHFFFAOYSA-N^checkY
^☒NcheckY (what is this?) (verify)

Mozavaptan (INN) is a vasopressin receptor antagonist marketed by Otsuka. In Japan, it was approved in October 2006 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH) due to ADH producing tumors.

References

Spreitzer H (November 20, 2006). "Neue Wirkstoffe - Conivaptan". Österreichische Apothekerzeitung (in German) (24/2006).
"Conivaptan hydrochloride". Molecule of the Month. Prous Science. November 2006. Archived from the original on 2012年02月13日.

CA inhibitors (at PT)	Acetazolamide
Loop (Na-K-Cl at AL)	Furosemide ^# Azosemide Bumetanide Etacrynic acid Etozolin Indacrinone Muzolimine Ozolinone Piretanide Tienilic acid ^‡ Torasemide
Thiazides (Na-Cl at DCT, Calcium-sparing)	Altizide Bendroflumethiazide Butizide Chlorothiazide Cyclopenthiazide Cyclothiazide Epitizide Hydrochlorothiazide Hydroflumethiazide Mebutizide Methyclothiazide Polythiazide Trichlormethiazide
Thiazide-likes (primarily DCT)	Chlortalidone Clofenamide Clopamide Clorexolone Fenquizone Indapamide Mefruside Meticrane Metolazone Quinethazone Xipamide

ESC blockers	Amiloride ^# Benzamil Triamterene
Aldosterone antagonists	Spirolactones Spironolactone ^# Canrenone Eplerenone Potassium canrenoate Nonsteroidal Finerenone

Other

Combination products

V_1A	Agonists: Felypressin Lypressin Ornipressin Selepressin Terlipressin Vasopressin (argipressin) Vasotocin (argiprestocin) Antagonists: Atosiban Balovaptan Conivaptan FR-218944 JNJ-17079166 JNJ-17308616 LIT-001 LY-307174 PF-184563 Relcovaptan RG7713 SRX246 SRX251 TC OT 39 WAY-267464 YM-218 YM-471 YM-35471
V_1B	Agonists: Desmopressin Felypressin Lypressin Ornipressin Terlipressin Vasopressin (argipressin) Vasotocin (argiprestocin) Antagonists: ABT-436 ABT-558 Brezivaptan Nelivaptan ORG-52186 (SCH-740935) TASP-0233278 TASP-0390325 Ligands: TASP-699
V₂	Agonists: Desmopressin Felypressin LIT-001 Lypressin Ornipressin TC OT 39 Terlipressin Vasopressin (argipressin) Vasotocin (argiprestocin) Antagonists: Conivaptan JNJ-17079166 Lixivaptan Mozavaptan RWJ-351647 Satavaptan Tolvaptan YM-471 YM-35471
Unsorted	Antagonists: Balovaptan Ribuvaptan RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate)

Others

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