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Monocarboxylate transporter 2

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
SLC16A7
Identifiers
Aliases SLC16A7 , MCT2, solute carrier family 16 member 7
External IDsOMIM: 603654; MGI: 1330284; HomoloGene: 20990; GeneCards: SLC16A7; OMA:SLC16A7 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr. Chromosome 12 (human) [1]
Band 12q14.1Start59,596,029 bp [1]
End59,789,855 bp [1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr. Chromosome 10 (mouse)[2]
Band 10|10 D3Start125,055,139 bp [2]
End125,225,334 bp [2]
RNA expression pattern
Bgee
Human Mouse (ortholog)
Top expressed in
  • right ventricle

  • renal medulla

  • vena cava

  • pericardium

  • sperm

  • cardia

  • myocardium of left ventricle

  • Skeletal muscle tissue of biceps brachii

  • superior surface of tongue

  • body of tongue
Top expressed in
  • spermatid

  • seminiferous tubule

  • spermatocyte

  • seminal vesicula

  • epithelium of stomach

  • right kidney

  • transitional epithelium of urinary bladder

  • human kidney

  • parotid gland

  • hair follicle
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9194

20503

Ensembl

ENSG00000118596

ENSMUSG00000020102

UniProt

O60669

O70451

RefSeq (mRNA)

NM_001270622
NM_001270623
NM_004731

NM_011391
NM_001358496
NM_001358915

RefSeq (protein)

NP_001257551
NP_001257552
NP_004722

NP_035521
NP_001345425
NP_001345844

Location (UCSC)Chr 12: 59.6 – 59.79 Mb Chr 10: 125.06 – 125.23 Mb
PubMed search[3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Monocarboxylate transporter 2 (MCT2) also known as solute carrier family 16 member 7 (SLC16A7) is a protein that in humans is encoded by the SLC16A7 gene.[5] MCT2 is a proton-coupled monocarboxylate transporter. It catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactic acid, branched-chain oxo acids derived from leucine, valine, and isoleucine, and the ketone bodies acetoacetate and beta-hydroxybutyrate. It also functions as high-affinity pyruvate transporter.

Both Northern blot analysis and inspection of the human expressed sequence tag (EST) database suggest relatively little expression of MCT2 in human tissues. As well, the sequence of MCT2 is far less conserved across species than that of MCT1 or MCT4 and there also appear to be considerable species differences in the tissue expression profile of this isoform.

Of the four known mammalian lactate transporters (MCTs 1-4), MCT2 harbors the highest affinity for lactate.[6] In parallel, MCT2 gene transcription has been demonstrated to respond with high-sensitivity to hypoxia, intracellular pH, and, to lactate.[7]

See also

[edit ]

References

[edit ]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000118596 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020102 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Garcia CK, Goldstein JL, Pathak RK, Anderson RG, Brown MS (Apr 1994). "Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle". Cell. 76 (5): 865–73. doi:10.1016/0092-8674(94)90361-1. PMID 8124722. S2CID 22137883.
  6. ^ Halestrap AP (Jan 2012). "The monocarboxylate transporter family--Structure and functional characterization". IUBMB Life. 64 (1): 1–9. doi:10.1002/iub.573. PMID 22131303. S2CID 24460891.
  7. ^ Caruso JP, Koch BJ, Benson PD, Varughese E, Monterey MD, Lee AE, Dave AM, Kiousis S, Sloan AE, Mathupala SP (Feb 2017). "pH, Lactate, and Hypoxia: Reciprocity in Regulating High-Affinity Monocarboxylate Transporter Expression in Glioblastoma". Neoplasia. 19 (2): 121–134. doi:10.1016/j.neo.2016年12月01日1. PMC 5238458 . PMID 28092823.

Further reading

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By group
SLC1–10
(1):
(2):
(3):
(4):
(5):
(6):
(7):
(8):
(9):
(10):
SLC11–20
(11):
(12):
(13):
(14):
(15):
(16):
(17):
(18):
(19):
(20):
SLC21–30
(21):
(22):
(23):
(24):
(25):
(26):
(27):
(28):
(29):
(30):
SLC31–40
(31):
(32):
(33):
(34):
(35):
(36):
(37):
(38):
(39):
(40):
SLC41–48
(41):
(42):
(43):
(44):
(45):
(46):
(47):
(48):
SLCO1–4
Symporter, Cotransporter
Antiporter (exchanger)


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