MCF2L
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Gene found in humans
| MCF2L | |||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | MCF2L , ARHGEF14, DBS, OST, MCF.2 cell line derived transforming sequence like | ||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 609499; MGI: 103263; HomoloGene: 11804; GeneCards: MCF2L; OMA:MCF2L - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||
Guanine nucleotide exchange factor DBS is a protein that in humans is encoded by the MCF2L gene.[5] [6]
References
[edit ]- ^ a b c GRCh38: Ensembl release 89: ENSG00000126217 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031442 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 4 (2): 141–50. doi:10.1093/dnares/4.2.141 . PMID 9205841.
- ^ "Entrez Gene: MCF2L MCF.2 cell line derived transforming sequence-like".
Further reading
[edit ]- Horii Y, Beeler JF, Sakaguchi K, Tachibana M, Miki T (Oct 1994). "A novel oncogene, ost, encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathways". The EMBO Journal. 13 (20): 4776–86. doi:10.1002/j.1460-2075.1994.tb06803.x. PMC 395416 . PMID 7957046.
- Rossman KL, Worthylake DK, Snyder JT, Siderovski DP, Campbell SL, Sondek J (Mar 2002). "A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange". The EMBO Journal. 21 (6): 1315–26. doi:10.1093/emboj/21.6.1315. PMC 125919 . PMID 11889037.
- Snyder JT, Worthylake DK, Rossman KL, Betts L, Pruitt WM, Siderovski DP, Der CJ, Sondek J (Jun 2002). "Structural basis for the selective activation of Rho GTPases by Dbl exchange factors". Nature Structural Biology. 9 (6): 468–75. doi:10.1038/nsb796. PMID 12006984. S2CID 13161854.
- Yamauchi J, Hirasawa A, Miyamoto Y, Kokubu H, Nishii H, Okamoto M, Sugawara Y, Tsujimoto G, Itoh H (Aug 2002). "Role of Dbl's big sister in the anti-mitogenic pathway from alpha1B-adrenergic receptor to c-Jun N-terminal kinase". Biochemical and Biophysical Research Communications. 296 (1): 85–92. doi:10.1016/S0006-291X(02)00839-2. PMID 12147231.
- Wennerberg K, Ellerbroek SM, Liu RY, Karnoub AE, Burridge K, Der CJ (Dec 2002). "RhoG signals in parallel with Rac1 and Cdc42". The Journal of Biological Chemistry. 277 (49): 47810–7. doi:10.1074/jbc.M203816200 . PMID 12376551.
- Cheng L, Mahon GM, Kostenko EV, Whitehead IP (Mar 2004). "Pleckstrin homology domain-mediated activation of the rho-specific guanine nucleotide exchange factor Dbs by Rac1". The Journal of Biological Chemistry. 279 (13): 12786–93. doi:10.1074/jbc.M313099200 . PMID 14701795.
- Ueda S, Kataoka T, Satoh T (Aug 2004). "Role of the Sec14-like domain of Dbl family exchange factors in the regulation of Rho family GTPases in different subcellular sites" (PDF). Cellular Signalling. 16 (8): 899–906. doi:10.1016/j.cellsig.200401007. hdl:20.500.14094/D1002967. PMID 15157669. Archived from the original (PDF) on 2020年07月21日. Retrieved 2020年07月21日.
- Kostenko EV, Mahon GM, Cheng L, Whitehead IP (Jan 2005). "The Sec14 homology domain regulates the cellular distribution and transforming activity of the Rho-specific guanine nucleotide exchange factor Dbs". The Journal of Biological Chemistry. 280 (4): 2807–17. doi:10.1074/jbc.M411139200 . PMID 15531584.
- Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.
- Ieguchi K, Ueda S, Kataoka T, Satoh T (Aug 2007). "Role of the guanine nucleotide exchange factor Ost in negative regulation of receptor endocytosis by the small GTPase Rac1". The Journal of Biological Chemistry. 282 (32): 23296–305. doi:10.1074/jbc.M700950200 . hdl:20.500.14094/D1004143 . PMID 17562712.
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