Protein-coding gene in the species Homo sapiens
LINE-1 type transposase domain containing 1 , also known as L1TD1 , is an RNA-binding protein that involved with self-renewal of undifferentiated human embryonic stem cells and cancer cell proliferation. L1TD1 has been reported to associate with the development of several cancers .
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^ a b c GRCh38: Ensembl release 89: ENSG00000240563 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000087166 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^
Iwabuchi KA, Yamakawa T, Sato Y, Ichisaka T, Takahashi K, Okita K, Yamanaka S (May 2011). "ECAT11/L1td1 is enriched in ESCs and rapidly activated during iPSC generation, but it is dispensable for the maintenance and induction of pluripotency" . PLOS ONE . 6 (5): e20461. Bibcode :2011PLoSO...620461I . doi :10.1371/journal.pone.0020461 PMC 3102727 PMID 21637830 .
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Närvä E, Rahkonen N, Emani MR, Lund R, Pursiheimo JP, Nästi J, Autio R, Rasool O, Denessiouk K, Lähdesmäki H, Rao A, Lahesmaa R (March 2012). "RNA-binding protein L1TD1 interacts with LIN28 via RNA and is required for human embryonic stem cell self-renewal and cancer cell proliferation" . Stem Cells . 30 (3): 452– 60. doi :10.1002/stem.1013 . PMC 3507993 PMID 22162396 .
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Wong RC, Ibrahim A, Fong H, Thompson N, Lock LF, Donovan PJ (April 2011). "L1TD1 is a marker for undifferentiated human embryonic stem cells" . PLOS ONE . 6 (4): e19355. Bibcode :2011PLoSO...619355W . doi :10.1371/journal.pone.0019355 PMC 3084827 PMID 21559406 .
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Yamamoto E, Toyota M, Suzuki H, Kondo Y, Sanomura T, Murayama Y, Ohe-Toyota M, Maruyama R, Nojima M, Ashida M, Fujii K, Sasaki Y, Hayashi N, Mori M, Imai K, Tokino T, Shinomura Y (October 2008). "LINE-1 hypomethylation is associated with increased CpG island methylation in Helicobacter pylori-related enlarged-fold gastritis" . Cancer Epidemiol Biomarkers Prev . 17 (10): 2555– 64. doi :10.1158/1055-9965.EPI-08-0112 . PMID 18842996 . S2CID 24719399 .
