Isotocyanozene

Pharmaceutical compound

Isotocyanozene
Identifiers

IUPAC name 1-[2-(diethylamino)ethyl]-2-[(4-prop-2-yloxyphenyl)methyl]benzimidazole-5-carbonitrile
Chemical and physical data
Formula	C₂₄H₃₀N₄O
Molar mass	390.531g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC(C)Oc1ccc(cc1)Cc1nc2cc(ccc2n1CCN(CC)CC)C#N
InChI InChI=InChI=1S/C24H30N4O/c1-5-27(6-2)13-14-28-23-12-9-20(17-25)15-22(23)26-24(28)16-19-7-10-21(11-8-19)29-18(3)4/h7-12,15,18H,5-6,13-14,16H2,1-4H3 Key:PCHKHUKJPIKAGU-UHFFFAOYSA-N

Isotocyanozene (5-cyano-isotodesnitazene) is a benzimidazole opioid analogue of isotonitazene which has been sold as a designer drug.^[1] It was first characterised by the drug checking service CanTEST, in September 2025 as an expected 'opioid' sample, and then later as an expected 'benzodiazepine' sample.^[2]^[3] Its μ-opioid in vitro activity is close to that of fentanyl.^[4] Following identification in human biological samples, isotocyanozene has been described to have opioid effects.^[5]

References

[edit ]

↑ "5-cyano Isotodesnitazene (hydrochloride)". www.caymanchem.com. Retrieved 2026年05月23日.
↑ "Community Notice 22nd of September 2025: Isotocyanozene found in 'opioid' capsule". CanTEST. Health and drug checking service, Canberra. September 2025.
↑ "Isotocyanozene found in 'opioid' capsule". The Know. 2025年09月22日. Retrieved 2025年09月23日.
↑ Curtis B, Lawes DJ, Persson M, Caldicott D, Green H, Norman C, et al. (2026年04月28日). "Identification of isotocyanozene at an Australian drug checking service". Forensic Chemistry. 49 100744. doi:10.1016/j.forc.2026.100744 . hdl:1885/733809832 .
↑ McHenry RD, Dunlop LC, Hudson S, Walters M, Dear JW, Lowe DJ (September 2025). "Isotocyanozene: detection of the 5-cyano analog of isotonitazene in human biological samples". Clinical Toxicology. 63 (9): 691–692. doi:10.1080/15563650.2025.2528990. PMID 40625206.