Irreversible agonist
From Wikipedia, the free encyclopedia
This article needs additional citations for verification . Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.
Find sources: "Irreversible agonist" – news · newspapers · books · scholar · JSTOR (January 2013) (Learn how and when to remove this message)
Find sources: "Irreversible agonist" – news · newspapers · books · scholar · JSTOR (January 2013) (Learn how and when to remove this message)
An irreversible agonist is a type of agonist that binds permanently to a receptor in such a manner that the receptor is permanently activated. It is distinct from a mere (reversible) agonist in that the association of an agonist to a receptor is reversible, whereas the binding of an irreversible agonist to a receptor is, at least in theory, irreversible. Oxymorphazone is an example of an irreversible agonist.[1] In practice, the distinction may be more a matter of degree, in which the binding affinity of an irreversible agonist is some orders of magnitude greater than that of an agonist.
Examples
[edit ]See also
[edit ]References
[edit ]- ^ Galetta S, Ling GS, Wolfin L, Pasternak GW (Sep 1982), "Receptor binding and analgesic properties of oxymorphazone", Life Sciences, 31 (12–13): 1389–92, doi:10.1016/0024-3205(82)90388-5, PMID 6183551
Stub icon
This pharmacology-related article is a stub. You can help Wikipedia by expanding it.