Harmalol
From Wikipedia, the free encyclopedia
| Names | |
|---|---|
| Preferred IUPAC name
1-Methyl-4,9-dihydro-3H-pyrido[4,3-b]indol-7-ol | |
| Other names
1-Methyl-4,9-dihydro-3H-β-carbolin-7-ol | |
| Identifiers | |
3D model (JSmol) |
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| ChemSpider | |
| ECHA InfoCard | 100.007.616 Edit this at Wikidata |
| EC Number |
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PubChem CID |
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| UNII | |
CompTox Dashboard (EPA) |
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| Properties | |
| C12H12N2O | |
| Molar mass | 200.241g·mol−1 |
| Appearance | Red solid[citation needed ] |
| Melting point | 100 to 105°C (212 to 221°F; 373 to 378K) (trihydrate)[1] |
Except where otherwise noted, data are given for materials in their standard state (at 25°C [77°F], 100kPa).
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Chemical compound
Harmalol is a bioactive β-carboline and a member of the harmala alkaloids.[2] [3]
Pharmacology
[edit ]Pharmacokinetics
[edit ]The elimination half-life of harmalol has been reported to be 30 to 49hours.[4]
Society and culture
[edit ]Legal status
[edit ]Australia
[edit ]Harmala alkaloids are considered Schedule 9 prohibited substances under the Poisons Standard (October 2015).[5] A Schedule 9 substance is a substance which may be abused or misused, the manufacture, possession, sale or use of which should be prohibited by law except when required for medical or scientific research, or for analytical, teaching or training purposes with approval of Commonwealth and/or State or Territory Health Authorities.[5]
Canada
[edit ]See also
[edit ]References
[edit ]- ↑ Thieme Chemistry (Hrsg.): RÖMPP Online – Version 3.37. Georg Thieme Verlag KG, Stuttgart, 27. September 2013.
- ↑ Sarkar S, Bhadra K (2014). "Binding of alkaloid harmalol to DNA: photophysical and calorimetric approach". J Photochem Photobiol B. 130: 272–80. Bibcode:2014JPPB..130..272S. doi:10.1016/j.jphotobiol.2013年11月02日1. PMID 24368411.
- ↑ El Gendy MA, Soshilov AA, Denison MS, El-Kadi AO (2012). "Harmaline and harmalol inhibit the carcinogen-activating enzyme CYP1A1 via transcriptional and posttranslational mechanisms". Food Chem Toxicol. 50 (2): 353–62. doi:10.1016/j.fct.2011年10月05日2. PMC 3281145 . PMID 22037238.
- ↑ Brito-da-Costa AM, Dias-da-Silva D, Gomes NG, Dinis-Oliveira RJ, Madureira-Carvalho Á (October 2020). "Toxicokinetics and Toxicodynamics of Ayahuasca Alkaloids N,N-Dimethyltryptamine (DMT), Harmine, Harmaline and Tetrahydroharmine: Clinical and Forensic Impact". Pharmaceuticals (Basel). 13 (11): 334. doi:10.3390/ph13110334 . PMC 7690791 . PMID 33114119.
- 1 2 Poisons Standard October 2015 https://www.comlaw.gov.au/Details/F2015L01534
- ↑ "Controlled Drugs and Substances Act". Department of Justice Canada. Retrieved 19 January 2026.
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