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HNRNPA0

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
HNRNPA0
Identifiers
Aliases HNRNPA0 , HNRPA0, heterogeneous nuclear ribonucleoprotein A0
External IDsOMIM: 609409; MGI: 1924384; HomoloGene: 136809; GeneCards: HNRNPA0; OMA:HNRNPA0 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr. Chromosome 5 (human) [1]
Band 5q31.2Start137,745,651 bp [1]
End137,754,363 bp [1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr. Chromosome 13 (mouse)[2]
Band 13|13 B1Start58,273,693 bp [2]
End58,276,370 bp [2]
RNA expression pattern
Bgee
Human Mouse (ortholog)
  • germinal epithelium

  • endothelial cell

  • middle temporal gyrus

  • embryo

  • tail of epididymis

  • retinal pigment epithelium

  • lactiferous duct

  • cartilage tissue

  • Pons

  • caput epididymis
  • hand

  • otolith organ

  • utricle

  • ganglionic eminence

  • abdominal wall

  • primitive streak

  • medial ganglionic eminence

  • ventricular zone

  • hair follicle

  • vas deferens
More reference expression data
BioGPS


Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10949

77134

Ensembl

ENSG00000177733

ENSMUSG00000007836

UniProt

Q13151

Q9CX86

RefSeq (mRNA)

NM_006805

NM_029872

RefSeq (protein)

NP_006796

NP_084148

Location (UCSC)Chr 5: 137.75 – 137.75 Mb Chr 13: 58.27 – 58.28 Mb
PubMed search[3] [4]
Wikidata

Heterogeneous nuclear ribonucleoprotein A0 is a protein that in humans is encoded by the HNRNPA0 gene.[5] [6]

This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind RNAs, followed by a glycine-rich C-terminus.[6]

References

[edit ]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000177733Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000007836Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Myer VE, Steitz JA (Dec 1995). "Isolation and characterization of a novel, low abundance hnRNP protein: A0". RNA. 1 (2): 171–82. PMC 1369071 . PMID 7585247.
  6. ^ a b "Entrez Gene: HNRPA0 heterogeneous nuclear ribonucleoprotein A0".

Further reading

[edit ]


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