HLA-DOB

Protein-coding gene in the species Homo sapiens

HLA-DOB

Identifiers

Aliases

HLA-DOB , DOB, major histocompatibility complex, class II, DO beta, HLA_DOB

External IDs

OMIM: 600629; MGI: 95925; HomoloGene: 1602; GeneCards: HLA-DOB; OMA:HLA-DOB - orthologs

Available structures

PDB

Human UniProt search: PDBe RCSB

List of PDB id codes
4I0P

Gene location (Human)
Chromosome 6 (human)
Chr.	Chromosome 6 (human) ^[1]
Chromosome 6 (human) Genomic location for HLA-DOB Genomic location for HLA-DOB
Band	6p21.32	Start	32,812,763 bp ^[1]
Band	6p21.32	End	32,820,466 bp ^[1]

Gene location (Mouse)
Chromosome 17 (mouse)
Chr.	Chromosome 17 (mouse)^[2]
Chromosome 17 (mouse) Genomic location for HLA-DOB Genomic location for HLA-DOB
Band	17 B1\|17 17.98 cM	Start	34,457,877 bp ^[2]
Band	17 B1\|17 17.98 cM	End	34,473,388 bp ^[2]

RNA expression pattern

Bgee

Human	Mouse (ortholog)
Top expressed in lymph node spleen appendix granulocyte bone marrow cell blood tonsil testicle monocyte rectum	Top expressed in mesenteric lymph nodes spleen blood submandibular gland subcutaneous adipose tissue white pulp thymus granulocyte embryo bone marrow
More reference expression data

BioGPS

More reference expression data

Gene ontology
Molecular function	MHC class II receptor activity MHC class II protein complex binding
Cellular component	lysosomal membrane endosome membrane lysosome membrane endosome integral component of membrane intracellular anatomical structure MHC class II protein complex
Biological process	negative regulation of antigen processing and presentation of peptide antigen via MHC class II antigen processing and presentation of peptide or polysaccharide antigen via MHC class II antigen processing and presentation immune system process antigen processing and presentation of exogenous peptide antigen via MHC class II immune response signal transduction adaptive immune response
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3112


15002

Ensembl

ENSG00000243496 ENSG00000241910 ENSG00000243612 ENSG00000239457 ENSG00000241386
ENSG00000241106


ENSMUSG00000041538

UniProt


P13765


n/a

RefSeq (mRNA)

NM_002120

NM_010389

RefSeq (protein)

NP_002111

n/a

Location (UCSC)

Chr 6: 32.81 – 32.82 Mb

Chr 17: 34.46 – 34.47 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human View/Edit Mouse

HLA class II histocompatibility antigen, DO beta chain is a protein that in humans is encoded by the HLA-DOB gene.^[5]

HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.^[5]

References

[edit ]

1 2 3 ENSG00000241910, ENSG00000243612, ENSG00000239457, ENSG00000241386, ENSG00000241106 GRCh38: Ensembl release 89: ENSG00000243496, ENSG00000241910, ENSG00000243612, ENSG00000239457, ENSG00000241386, ENSG00000241106 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041538 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: HLA-DOB major histocompatibility complex, class II, DO beta".

Beck S, Kelly A, Radley E, etal. (1992). "DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing". J. Mol. Biol. 228 (2): 433–41. doi:10.1016/0022-2836(92)90832-5. PMID 1453454.
Piatier-Tonneau D, Gastinel LN, Amblard F, etal. (1991). "Interaction of CD4 with HLA class II antigens and HIV gp120". Immunogenetics. 34 (2): 121–8. doi:10.1007/BF00211424. PMID 1869305. S2CID 10116507.
Rosenstein Y, Burakoff SJ, Herrmann SH (1990). "HIV-gp120 can block CD4-class II MHC-mediated adhesion". J. Immunol. 144 (2): 526–31. doi:10.4049/jimmunol.144.2.526 . PMID 1967269.
Bowman MR, MacFerrin KD, Schreiber SL, Burakoff SJ (1991). "Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules". Proc. Natl. Acad. Sci. U.S.A. 87 (22): 9052–6. doi:10.1073/pnas.87.22.9052 . PMC 55099 . PMID 1978941.
Jonsson AK, Rask L (1989). "Human class II DNA and DOB genes display low sequence variability". Immunogenetics. 29 (6): 411–3. doi:10.1007/BF00375872. PMID 2499532. S2CID 5481750.
Clayton LK, Sieh M, Pious DA, Reinherz EL (1989). "Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding". Nature. 339 (6225): 548–51. Bibcode:1989Natur.339..548C. doi:10.1038/339548a0 . PMID 2543930. S2CID 4246781.
Diamond DC, Sleckman BP, Gregory T, etal. (1988). "Inhibition of CD4+ T cell function by the HIV envelope protein, gp120". J. Immunol. 141 (11): 3715–7. doi:10.4049/jimmunol.141.11.3715 . PMID 2846691.
Tonnelle C, DeMars R, Long EO (1986). "DO beta: a new beta chain gene in HLA-D with a distinct regulation of expression". EMBO J. 4 (11): 2839–47. doi:10.1002/j.1460-2075.1985.tb04012.x. PMC 554587 . PMID 2998758.
Servenius B, Rask L, Peterson PA (1987). "Class II genes of the human major histocompatibility complex. The DO beta gene is a divergent member of the class II beta gene family". J. Biol. Chem. 262 (18): 8759–66. doi:10.1016/S0021-9258(18)47481-9 . PMID 3036827.
Andrieu JM, Even P, Venet A (1986). "AIDS and related syndromes as a viral-induced autoimmune disease of the immune system: an anti-MHC II disorder. Therapeutic implications". AIDS Research. 2 (3): 163–74. doi:10.1089/aid.1.1986年2月16日3. PMID 3489470.
Houlgatte R, Scarmato P, el Marhomy S, etal. (1994). "HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4". J. Immunol. 152 (9): 4475–88. doi:10.4049/jimmunol.152.9.4475 . PMID 7512597.
Chirmule N, McCloskey TW, Hu R, etal. (1995). "HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71)". J. Immunol. 155 (2): 917–24. doi:10.4049/jimmunol.155.2.917 . PMID 7541827.
Rowell JF, Stanhope PE, Siliciano RF (1995). "Endocytosis of endogenously synthesized HIV-1 envelope protein. Mechanism and role in processing for association with class II MHC". J. Immunol. 155 (1): 473–88. doi:10.4049/jimmunol.155.1.473. PMID 7602119. S2CID 19994352.
Chen YH, Böck G, Vornhagen R, etal. (1994). "HIV-1 gp41 binding proteins and antibodies to gp41 could inhibit enhancement of human Raji cell MHC class I and II expression by gp41". Mol. Immunol. 31 (13): 977–82. doi:10.1016/0161-5890(94)90092-2. PMID 8084338.
Chirmule N, Wang XP, Hu R, etal. (1994). "Envelope glycoproteins of HIV-1 interfere with T-cell-dependent B cell differentiation: role of CD4-MHC class II interaction in the effector phase of T cell help". Cell. Immunol. 155 (1): 169–82. doi:10.1006/cimm.1994.1110 . PMID 8168144.
Callahan KM, Rowell JF, Soloski MJ, etal. (1993). "HIV-1 envelope protein is expressed on the surface of infected cells before its processing and presentation to class II-restricted T lymphocytes". J. Immunol. 151 (6): 2928–42. doi:10.4049/jimmunol.151.6.2928 . PMID 8376762.
Glynne R, Kerr LA, Mockridge I, etal. (1993). "The major histocompatibility complex-encoded proteasome component LMP7: alternative first exons and post-translational processing". Eur. J. Immunol. 23 (4): 860–6. doi:10.1002/eji.1830230414. PMID 8458375. S2CID 44733094.
Beck S, Abdulla S, Alderton RP, etal. (1996). "Evolutionary dynamics of non-coding sequences within the class II region of the human MHC". J. Mol. Biol. 255 (1): 1–13. doi:10.1006/jmbi.1996.0001. PMID 8568858.
Liljedahl M, Kuwana T, Fung-Leung WP, etal. (1996). "HLA-DO is a lysosomal resident which requires association with HLA-DM for efficient intracellular transport". EMBO J. 15 (18): 4817–24. doi:10.1002/j.1460-2075.1996.tb00862.x. PMC 452218 . PMID 8890155.
Ruff AL, Guarnieri FG, Staveley-O'Carroll K, etal. (1997). "The enhanced immune response to the HIV gp160/LAMP chimeric gene product targeted to the lysosome membrane protein trafficking pathway". J. Biol. Chem. 272 (13): 8671–8. doi:10.1074/jbc.272.13.8671 . PMID 9079699.

v t e Major histocompatibility complex classes
MHC class I	HLA-A HLA-B HLA-C HLA-E HLA-F HLA-G
MHC class II	HLA-DM α β HLA-DO α β HLA-DP α1 β1 HLA-DQ α1 α2 β1 β2 β3 HLA-DR α β1 β3 β4 β5
Other	Human leukocyte antigen Minor histocompatibility antigen Blood transfusion Arrestin Calgranulin Human blood group systems Cell adhesion molecules Cluster of differentiation

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References

Further reading