Jump to content
Wikipedia The Free Encyclopedia

GFRA3

From Wikipedia, the free encyclopedia
(Redirected from GFRα3)
Protein-coding gene in the species Homo sapiens
GFRA3
Available structures
PDB Ortholog search: PDBe RCSB
List of PDB id codes

2GH0

Identifiers
Aliases GFRA3 , GDNFR3, GDNF family receptor alpha 3
External IDsOMIM: 605710; MGI: 1201403; HomoloGene: 1146; GeneCards: GFRA3; OMA:GFRA3 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr. Chromosome 5 (human) [1]
Band 5q31.2Start138,252,380 bp [1]
End138,274,621 bp [1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr. Chromosome 18 (mouse)[2]
Band 18|18 B1Start34,822,951 bp [2]
End34,853,440 bp [2]
RNA expression pattern
Bgee
Human Mouse (ortholog)
  • spinal ganglia

  • trigeminal ganglion

  • tibial nerve

  • testicle

  • sural nerve

  • gonad

  • muscle layer of sigmoid colon

  • vena cava

  • seminal vesicula

  • mucosa of transverse colon
  • lumbar spinal ganglion

  • trigeminal ganglion

  • superior cervical ganglion

  • external carotid artery

  • embryo

  • urethra

  • female urethra

  • male urethra

  • internal carotid artery

  • carotid body
More reference expression data
BioGPS
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

2676

14587

Ensembl

ENSG00000146013

ENSMUSG00000024366

UniProt

O60609

O35118

RefSeq (mRNA)

NM_001496

NM_010280

RefSeq (protein)

NP_001487

NP_034410

Location (UCSC)Chr 5: 138.25 – 138.27 Mb Chr 18: 34.82 – 34.85 Mb
PubMed search[3] [4]
Wikidata

GDNF family receptor alpha-3 (GFRα3), also known as the artemin receptor, is a protein that in humans is encoded by the GFRA3 gene.[5] [6]

Function

[edit ]

The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the artemin ligand.[6]

In mouse models of osteoarthritis, GFRα3 was upregulated in sensory nerves. Treating arthritic mice with monoclonal antibodies that bind to GFRα3 prevents artemin from binding there and signaling pain. Treated mice were able to use their limbs again two hours post-treatment.[7]

See also

[edit ]

References

[edit ]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000146013Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024366Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Jing S, Yu Y, Fang M, Hu Z, Holst PL, Boone T, Delaney J, Schultz H, Zhou R, Fox GM (Dec 1997). "GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family". The Journal of Biological Chemistry. 272 (52): 33111–7. doi:10.1074/jbc.272.52.33111 . PMID 9407096.
  6. ^ a b "Entrez Gene: GFRA3 GDNF family receptor alpha 3".
  7. ^ Irving, Michael (2022年01月31日). ""Pain pathway" a promising new drug target to treat osteoarthritis pain". New Atlas. Retrieved 2022年02月01日.

Further reading

[edit ]
PDB gallery
Angiopoietin
CNTF
EGF (ErbB)
EGF
(ErbB1/HER1)
ErbB2/HER2
ErbB3/HER3
ErbB4/HER4
FGF
FGFR1
FGFR2
FGFR3
FGFR4
Unsorted
HGF (c-Met)
IGF
IGF-1
IGF-2
Others
LNGF (p75NTR)
PDGF
RET (GFL)
GFRα1
GFRα2
GFRα3
GFRα4
Unsorted
SCF (c-Kit)
TGFβ
Trk
TrkA
TrkB
TrkC
VEGF
Others


Stub icon

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

AltStyle によって変換されたページ (->オリジナル) /