GFM2

Protein-coding gene in the species Homo sapiens

GFM2

Identifiers

GFM2 , EF-G2mt, EFG2, MRRF2, MST027, RRF2, RRF2mt, hEFG2, mEF-G 2, MSTP027, G elongation factor, mitochondrial 2, G elongation factor mitochondrial 2, RRF, GTP dependent ribosome recycling factor mitochondrial 2

External IDs

OMIM: 606544; MGI: 2444783; HomoloGene: 6238; GeneCards: GFM2; OMA:GFM2 - orthologs

Gene location (Human)
Chromosome 5 (human)
Chr.	Chromosome 5 (human) ^[1]
Chromosome 5 (human) Genomic location for GFM2 Genomic location for GFM2
Band	5q13.3	Start	74,721,206 bp ^[1]
Band	5q13.3	End	74,767,147 bp ^[1]

Gene location (Mouse)
Chromosome 13 (mouse)
Chr.	Chromosome 13 (mouse)^[2]
Chromosome 13 (mouse) Genomic location for GFM2 Genomic location for GFM2
Band	13\|13 D1	Start	97,274,445 bp ^[2]
Band	13\|13 D1	End	97,317,703 bp ^[2]

RNA expression pattern

Bgee

Human	Mouse (ortholog)
Top expressed in myocardium of left ventricle tibialis anterior muscle bronchial epithelial cell deltoid muscle epithelium of nasopharynx secondary oocyte mucosa of ileum cardiac muscle tissue of right atrium right uterine tube nasal epithelium	Top expressed in muscle of thigh otic vesicle sternocleidomastoid muscle otic placode temporal muscle right kidney saccule triceps brachii muscle digastric muscle skeletal muscle tissue
More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	translation elongation factor activity nucleotide binding GTP binding protein binding GTPase activity
Cellular component	mitochondrial matrix mitochondrion
Biological process	mitochondrial translational termination mitochondrial translational elongation ribosome disassembly protein biosynthesis mitochondrial translation translational elongation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


84340


320806

Ensembl


ENSG00000164347


ENSMUSG00000021666

UniProt


Q969S9


Q8R2Q4

RefSeq (mRNA)

NM_001281302
NM_032380
NM_170681
NM_170691

NM_001146043
NM_001271463
NM_001271464
NM_001271465
NM_177266

RefSeq (protein)

NP_001268231
NP_115756
NP_733781
NP_733792
NP_733792.1

NP_001139515
NP_001258392
NP_001258393
NP_001258394
NP_796240

Location (UCSC)

Chr 5: 74.72 – 74.77 Mb

Chr 13: 97.27 – 97.32 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human View/Edit Mouse

Ribosome-releasing factor 2, mitochondrial is a protein that in humans is encoded by the GFM2 gene. ^[5]^[6] Unlike the other EF-G homolog GFM1, GFM2 functions as a Ribosome Recycling Factor in termination.^[7]

References

[edit ]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164347 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021666 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hammarsund M, Wilson W, Corcoran M, Merup M, Einhorn S, Grandér D, Sangfelt O (November 2001). "Identification and characterization of two novel human mitochondrial elongation factor genes, hEFG2 and hEFG1, phylogenetically conserved through evolution". Human Genetics. 109 (5): 542–50. doi:10.1007/s00439-001-0610-5. PMID 11735030. S2CID 24508386.
^ "Entrez Gene: GFM2 G elongation factor, mitochondrial 2".
^ Tsuboi M, Morita H, Nozaki Y, Akama K, Ueda T, Ito K, Nierhaus KH, Takeuchi N (August 2009). "EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis". Molecular Cell. 35 (4): 502–10. doi:10.1016/j.molcel.2009年06月02日8 . PMID 19716793.