Ephedra (plant)

As of June 2021^[update] , Plants of the World Online accepted the following species:^[17]

• Ephedra alata Decne. – North Africa, Arabian Peninsula
• Ephedra altissima Desf. non-Bové (1834), non-Delile (1813), non-Buch (1828) (High-climbing jointfir) – North Africa, Canary Islands
• Ephedra americana Humb. & Bonpl. ex Willd. – Bolivia, Ecuador, Peru, Argentina, Chile
• Ephedra antisyphilitica Berland ex C.A.Mey. – Clapweed, Erect Ephedra – Texas, Oklahoma, New Mexico, Nuevo León, Coahuila, Chihuahua
• Ephedra aphylla Forssk. – eastern Mediterranean from Libya and Cyprus to the Persian Gulf
• ×ばつ arenicola (page does not exist)">Ephedra ×ばつ arenicola H.C.Cutler – Arizona, Utah (hybrid, E. cutleri ×ばつ E. torreyana)
• Ephedra aspera Engelm. ex S.Watson – Boundary Ephedra, Pitamoreal – Texas, New Mexico, Arizona, Utah, Nevada, California, Chihuahua, Durango, Zacatecas, Sinaloa, Sonora, Baja California
• Ephedra aurantiaca Takht. & Pachom. – Caucasus, Kazakhstan, Turkmenistan
• Ephedra aurea Brullo et al.
• Ephedra boelckei F.A.Roig – Argentina
• Ephedra botschantzevii Pachom. – Kazakhstan, Tuva region of Siberia
• Ephedra breana Phil. (frutilla de campo) – Peru, Bolivia, Chile, Argentina
• Ephedra brevifoliata Ghahr. – Iran
• Ephedra californica S.Watson – California Ephedra, California Jointfir – California, western Arizona, Baja California
• Ephedra chengiae Yang & Ferguson
• Ephedra chilensis C.Presl – Pingo-pingo - Chile, Argentina
• Ephedra compacta Rose – widespread in much of Mexico
• Ephedra coryi E.L.Reed (Cory's Ephedra) – Texas, New Mexico
• Ephedra cutleri Peebles – Navajo Ephedra, Cutler's Ephedra, Cutler Mormon-tea, Cutler's Jointfir – Colorado, Utah, Arizona, New Mexico, Wyoming
• Ephedra dahurica Turcz. – Siberia, Mongolia
• Ephedra dawuensis Y.Yang – Sichuan
• Ephedra distachya L. – Joint-pine, Jointfir – southern Europe and central Asia from Portugal to Kazakhstan
• ×ばつ eleutherolepis (page does not exist)">Ephedra ×ばつ eleutherolepis V.A.Nikitin – Tajikistan (hybrid E. intermedia ×ばつ E. strobilacea)
• Ephedra equisetina Bunge – Ma huang – Caucasus, Central Asia, Siberia, Mongolia, Gansu, Hebei, Inner Mongolia, Ningxia, Qinghai, Shanxi, Xinjiang
• Ephedra fasciculata A.Nelson – Arizona Ephedra, Arizona Jointfir, Desert Mormon-tea – Arizona, California, Nevada, Utah
• Ephedra fedtschenkoae Paulsen – Central Asia, Siberia, Mongolia, Xinjiang
• Ephedra foeminea Forssk. – North Africa, Somalia, Balkans, Italy, Middle East; naturalized in Santa Barbara County of California
• Ephedra foliata Boiss. ex C.A.Mey. (Shrubby horsetail) – North Africa, Somalia, Middle East, India
• Ephedra fragilis Desf. (joint pine) – Mediterranean, Canary Islands, Madeira
• Ephedra frustillata Miers – Patagonian Ephedra – Chile, Argentina
• Ephedra funerea Coville & C.V.Morton – Death Valley Ephedra, Death Valley Jointfir – California, Arizona, Nevada
• Ephedra gerardiana Wall. ex Klotzsch & Garcke – Gerard's Jointfir, Shan Ling Ma Huang – Himalayas, Tibet, Yunnan, Siberia, Central Asia
• Ephedra gracilis Phil. ex Stapf
• Ephedra holoptera Riedl – Iran
• Ephedra intermedia Schrenk & C.A.Mey. (Zhong Ma Huang) – China, Siberia, Central Asia, Himalayas, Iran, Pakistan
• Ephedra kardangensis P.Sharma & P.L.Uniyal – western Himalayas
• Ephedra khurikensis P.Sharma & P.L.Uniyal – western Himalayas
• Ephedra laristanica Assadi – Iran
• Ephedra likiangensis Florin – Guizhou, Sichuan, Tibet, Yunnan
• Ephedra lomatolepis Schrenk – Kazakhstan, Tuva region of Siberia
• Ephedra major Host – Mediterranean, Middle East, Central Asia; from Canary Islands to Kashmir
• Ephedra milleri Freitag & Maier-St. – Oman, Yemen
• Ephedra minuta Florin – Qinghai, Sichuan
• Ephedra monosperma J.G.Gmel. ex C.A.Mey. (dan zi ma huang) – Siberia, Mongolia, much of China including Tibet and Xinjiang
• Ephedra multiflora Phil. ex Stapf – Chile, Argentina
• Ephedra nevadensis S.Watson – Nevada Ephedra, Nevada Jointfir, Nevada Mormon-tea – Baja California, California, Arizona, Nevada, Utah, Oregon
• Ephedra ochreata Miers – Argentina
• Ephedra oxyphylla Riedl – Afghanistan
• Ephedra pachyclada Boiss. – Middle East from Sinai and Yemen to Pakistan
• Ephedra pangiensis Rita Singh & P.Sharma
• Ephedra pedunculata Engelm. ex S.Watson – Vine Ephedra, Vine Jointfir – Texas, Chihuahua, Coahuila, Durango, San Luis Potosí, Nuevo León, Zacatecas
• Ephedra pentandra Pachom. – Iran
• Ephedra procera Fisch. & C.A.Mey. − Iran, Caucasus
• Ephedra przewalskii Stapf – Central Asia, Mongolia, Pakistan, Gansu, Inner Mongolia, Ningxia, Qinghai, Tibet
• Ephedra pseudodistachya Pachom. – Siberia, Mongolia
• Ephedra regeliana Florin – Xi Zi Ma Huang – Central Asia, Siberia, Pakistan, Xinjiang
• Ephedra rhytidosperma Pachom., syn. E. lepidosperma C.Y.Cheng – Gansu, Inner Mongolia, Ningxia, Mongolia
• Ephedra rituensis Y.Yang, D.Z.Fu & G.H.Zhu – Qinghai, Xinjiang, Tibet
• Ephedra rupestris Benth. – Ecuador, Peru, Bolivia, Argentina
• Ephedra sarcocarpa Aitch. & Hemsl. – Pakistan, Afghanistan
• Ephedra saxatilis (Stapf) Royle ex Florin
• Ephedra sinica Stapf – Cao Ma Huang, Chinese ephedra – Mongolia, Siberia, Primorye, Manchuria
• Ephedra somalensis Freitag & Maier-St. – Somalia, Eritrea
• Ephedra stipitata Biswas & Rita Singh
• Ephedra strobilacea Bunge – Iran, Central Asia
• Ephedra strongylensis Brullo et al.
• Ephedra sumlingensis P.Sharma & P.L.Uniyal – western Himalayas
• Ephedra tilhoana Maire – Chad
• Ephedra torreyana S.Watson – Torrey's Ephedra, Torrey's Jointfir, Torrey's Mormon-tea, Cañutillo – Nevada, Utah, Colorado, Arizona, New Mexico, Texas, Chihuahua
• Ephedra transitoria Riedl – Iraq, Syria, Palestine, Saudi Arabia
• Ephedra triandra Tul. − Bolivia, Argentina
• Ephedra trifurca Torrey ex S.Watson – Longleaf Ephedra, Longleaf Jointfir, Longleaf Mormon-tea, Popotilla, Teposote – California, Arizona, New Mexico, Texas, Chihuahua, Sonora, Baja California
• Ephedra trifurcata Zöllner
• Ephedra tweedieana C.A.Mey. – Brazil, Argentina, Uruguay
• Ephedra viridis Coville – Green Ephedra, Green Mormon-tea – California, Nevada, Utah, Arizona, New Mexico, Colorado, Wyoming, South Dakota, Oregon
• Ephedra vvedenskyi Pachom. – Iran, Caucasus, Turkmenistan
• Ephedra yangthangensis Prabha Sharma & Rita Singh – Yangthang to Ka, Leo, Nako, Chango, Chulling, Sumdo, Hoorling and Lira of Kinnaur district of Himachal Pradesh^[18]

The genus is found worldwide, in desert regions, but not in Australia.^[3]

Ephedraceae are adapted to extremely arid regions, growing often in high sunny habitats, and occur as high as 4000 m above sea level in both the Andes and the Himalayas.^[3] They make up a significant part of the North American Great Basin sage brush ecosystem.

Today, Ephedra plants are found no further south than 3°N in the Saharo-Arabian zone. However, researchers have discovered evidence of this drought-resistant plant living over 1,000 km further south at Oldupai Gorge around one million years ago, based on fossil pollen, preserved tap roots, and supporting indicators of arid conditions.^[19]

Remains of a buried Neanderthal found at Shanidar cave in Iraqi Kurdistan, over 50,000 years old was found associated with Ephedra pollen among those of other plants. While some authors have suggested that these represent plant remains deliberately buried alongside the Neanderthal, other authors have suggested that natural agents like bees may have been responsible for the accumulation of pollen.^[20]

In addition, archaeological remains of Ephedra dating back 15,000 years have been discovered at Taforalt Cave in Morocco. Fossil cones of Ephedra were found concentrated in the cemetery area, specifically within a human burial.^[21]

The Ephedra alkaloids, ephedrine and pseudoephedrine – constituents of E. sinica and other members of the genus – have sympathomimetic and decongestant qualities,^[22] and have been used as dietary supplements, mainly for weight loss.^[23] The drug ephedrine is used to prevent low blood pressure during spinal anesthesia.^[22]

In the United States, ephedra supplements were banned from the market in the early 21st century due to serious safety risks.^[23] Plants of the genus Ephedra, including E. sinica and others, were used in traditional medicine for treating headache and respiratory infections, but there is no scientific evidence they are effective or safe for these purposes.^[23]

Ephedra has also had a role as a precursor in the clandestine manufacture of methamphetamine.^[24]

Alkaloids obtained from the species of Ephedra used in herbal medicines, which are used to synthetically prepare pseudoephedrine and ephedrine, can cause cardiovascular events.^[22] These events have been associated with arrhythmias, palpitations, tachycardia and myocardial infarction.^[22] Caffeine consumption in combination with ephedrine has been reported to increase the risk of these cardiovascular events.^{[22] [23]}

The earliest uses of Ephedra species (mahuang) for specific illnesses date back to 5000 BC. Ephedrine and its isomers were isolated in 1881 from Ephedra distachya and characterized by the Japanese organic chemist Nagai Nagayoshi. His work to access Ephedra's active ingredients to isolate a pure pharmaceutical substance led to the systematic production of semi-synthetic derivatives thereof and is still relevant today. Three species, Ephedra sinica , Ephedra vulgaris, and to a lesser extent Ephedra equisetina , are commercially grown in Mainland China as a source for natural ephedrines and isomers for use in pharmaceuticals. E. sinica and E. distachya usually carry six optically active phenylethylamines, mostly ephedrine and pseudoephedrine with minor amounts of norephedrine, norpseudoephedrine as well as the three methylated analogs. Reliable information on the total alkaloid content of the crude drug is difficult to obtain. Based on HPLC analyses in industrial settings, the concentrations of total alkaloids in dried Herba Ephedra ranged between 1 and 4%, and in some cases up to 6%.^[25]

For a review of the alkaloid distribution in different species of the genus Ephedra see Jian-fang Cui (1991).^[26] Other American and European species of Ephedra, e.g. Ephedra nevadensis (Nevada Mormon tea) have not been systematically assayed; based on unpublished field investigations, they contain very low levels (less than 0.1%) or none at all.^[27]

• Ephedra viridis (Plants for a Future Database)
• Usage in Chinese Medicine
• Ephedra fact sheet, NIH National Center for Complementary and Integrative Health
• Ephedrea (Evidence and dosing) Archived 22 September 2017 at the Wayback Machine, Mayo Clinic
• Ephedra – Clinical summary and mechanism of action, MSKCC Memorial Sloan Kettering Cancer Center
• Ephedraceae of Mongolia in FloraGREIF Archived 4 April 2016 at the Wayback Machine